Results 321 to 330 of about 905,894 (352)
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The effect of null C4 alleles on complement function
Clinical Immunology and Immunopathology, 1985C4 is encoded at two polymorphic genetic loci (C4A and B), and "null" or unexpressed alleles are relatively common. An increased frequency of nulls has been reported in a variety of diseases. In the present study, C4 allotypes and C4 hemolytic efficiencies (the ratios of functional to antigenic levels) were determined for a population of 75 normal ...
Linda S. Beischel +9 more
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Complement components (C3, C4) in childhood asthma
The Indian Journal of Pediatrics, 2005To assess the involvement of complements (C3, C4) in the pathophysiology of bronchial asthma.Selection of patients (n = 64) were made according to the recommended international criteria for diagnosis and classification of asthma. Serum levels of complement components (C3, C4) were measured by radial immunodiffusion technique in 64 Libyan children (age:
A. S. M. Giasuddin +2 more
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Interaction of nucleophilic compounds with complement component C4
Comparative Immunology, Microbiology and Infectious Diseases, 1988Drugs which induce systemic lupus erythematosus as a toxic side effect have been shown to inhibit the covalent binding of C4, which is an important event in immune complex clearance in normal individuals. Human C4 is encoded at two polymorphic loci, C4A and C4B within the Major Histocompatibility Complex and patients with idiopathic SLE are more likely
K. E. Parker +3 more
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Complement Components, C3 and C4, and the Metabolic Syndrome
Current Diabetes Reviews, 2018Introduction: Increased systemic inflammation plays a significant role in the development of adult cardiometabolic diseases such as insulin resistance, dyslipidemia, atherosclerosis, and hypertension. The complement system is a part of the innate immune system and plays a key role in the regulation of inflammation.
Melanie M. Copenhaver +2 more
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Family studies of complement C4 and HLA in man
Human Genetics, 1981At least 12 different C4 gene products with a three band pattern have been identified after electrophoresis of sera pretreated with neuraminidase. Segregation analysis showed at least 12 different C4 haplotypes (or supergenes), of which five represent a single gene product and seven are duplications each composed of an F and an S gene.
John Mortensen +4 more
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The complement component C4 in sudden infant death
European Journal of Pediatrics, 1999The aim of the present study was to compare partial deletions of the complement C4 gene in victims of totally unexplained sudden infant death (SID) (n = 89) and borderline SID (n = 15) with and without slight infections prior to death, in cases of infectious death (n = 19), and in living infants with and without infections (n = 84).
A. K. Stave +3 more
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Complement C4 Phenotypes in Dementia of the Alzheimer Type
Human Heredity, 1988Complement C4 phenotype distribution was studied in 64 patients with dementia of the Alzheimer type. In contrast to reported findings we failed to find a significant association between C4B2 gene frequency and Alzheimer's dementia.
J.C. Pronk +3 more
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Complement factor C4 activation in patients with hereditary angioedema
Clinical Biochemistry, 2017Low complement factor C4 is usually considered a valuable screening tool for patients with the potentially life-threatening hereditary angioedema with C1-inhibitor (C1-INH) deficiency (C1-INH-HAE). However, there are patients with C1-INH-HAE presenting with normal C4 levels.
Anne Aabom, Anette Bygum, Claus Koch
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Complement Inhibitors Targeting C3, C4, and C5 [PDF]
, 2000 Activation of the complement system (Fig. 1) is the key to the development of normal inflammatory responses against foreign pathogens. During the course of this activation process a number of biological events are initiated, including generation of small peptides that induce local inflammatory responses, tagging of foreign pathogens with complement ...
John D. Lambris +2 more
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Isolation of the Fourth Component (C4) of Rat Complement
The Journal of Immunology, 1979Abstract The fourth component of rat complement was purified to homogeneity by sequential chromatography of rat plasma in benzamidine on QAE-A50, SP-C50, hydroxyapatite, and gel filtration on Bio-Gel A 1.5. The final material was homogeneous on SDS-PAGE analysis and had a calculated m.w. of 198,000. A monospecific antibody against rat C4
M R, Daha, L A, van ES
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