Results 101 to 110 of about 11,949 (217)

Associação do alótipo raro C4A6 do sistema complemento com a doença cardíaca reumática Association of the C4A6 rare allotype with rheumatic heart disease

open access: yesRevista Brasileira de Reumatologia, 2004
OBJETIVO: determinar se os alótipos do Fator B (BF), C2 e C4 (C4A e C4B) do sistema complemento poderiam ser marcadores para a doença cardíaca reumática (DCR) na população brasileira. MÉTODOS: foram estudados 49 pacientes com DCR crônica.
Iara Jose de Messias-Reason   +2 more
doaj   +1 more source

Natural antibodies and CRP drive anaphylatoxin production by urate crystals

open access: yesScientific Reports, 2022
In gout, crystallization of uric acid in the form of monosodium urate (MSU) leads to a painful inflammatory response. MSU crystals induce inflammation by activating the complement system and various immune cell types, and by inducing necrotic cell death.
Anne Kathrin Wessig   +7 more
doaj   +1 more source

Machine Learning Model for an App‐Based Tool to Assist With the Diagnosis of Canine Atopic Dermatitis

open access: yesVeterinary Dermatology, EarlyView.
Canine atopic dermatitis (cAD) is a chronic condition requiring life‐long management. Accurate diagnosis can be challenging, with no reliable diagnostic test. This study aimed to generate a simple diagnostic model for cAD. This model is a relevant prototype for an app‐based tool to support general practitioners in the diagnosis of cAD alongside ...
Xavier Langon   +2 more
wiley   +1 more source

Serum proteomic analysis uncovers novel serum biomarkers for depression

open access: yesFrontiers in Psychiatry
ObjectiveThe identification of depression primarily relies on the clinical symptoms and psychiatric evaluation of the patient, in the absence of objective and quantifiable biomarkers within clinical settings.
Aihong Guo   +12 more
doaj   +1 more source

Tolerability and Feasibility of Minimally Invasive Canine Skin Sampling: Excellent Tolerability Meets Transcriptomic Challenges

open access: yesVeterinary Dermatology, EarlyView.
ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann   +2 more
wiley   +1 more source

Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model. [PDF]

open access: yes, 2013
BackgroundThe aneurysm clip impact-compression model of spinal cord injury (SCI) is a standard injury model in animals that closely mimics the primary mechanism of most human injuries: acute impact and persisting compression.
Boutros, Paul C   +5 more
core   +3 more sources

Spatial heterogeneity in microglia‐complement crosstalk: Implications for synaptic pruning in Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss, as a key pathological feature in its early stages. Recent studies have highlighted the central role of microglia–complement interactions in synaptic pruning.
Qiuyan Ye   +10 more
wiley   +1 more source

Lewis meets Brouwer: constructive strict implication

open access: yes, 2017
C. I. Lewis invented modern modal logic as a theory of "strict implication". Over the classical propositional calculus one can as well work with the unary box connective.
Litak, Tadeusz, Visser, Albert
core   +1 more source

Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers

open access: yesAndrology, Volume 14, Issue 2, Page 555-570, February 2026.
Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco   +6 more
wiley   +1 more source

Infektív, genetikai és complement aktivációs tényezők szerepének vizsgálata az autoimmun betegségek patogenezisében = Investigation of the role of infective, genetic and complement activation factor in the pathogenesis of autoimmune disorders [PDF]

open access: yes, 2008
Az MBL2 gén polimorfizmusa az SLE kialakulásának rizikó faktora. 315 SLE-s betegben és 182 kontrollban az MBL2 polimorfizmust vizsgáltuk. Kimutattuk, hogy az MBL2 polimorfizmusában a homozigóta SLE-s betegekben szignifikánsan fiatalabb életkorban (p=0 ...
Backhauszné dr. Takács, Edit Katalin   +7 more
core  

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