Results 171 to 180 of about 9,987 (203)

C4b-Binding protein, a regulatory protein of complement

Immunologic Research, 1991
Despite the wealth of structural and functional information on C4BP, it is clear that several aspects of C4BP biology and regulation under normal conditions and in the acute-phase response remain unresolved. Studies to identify which interleukin and cytokines regulate C4BP expression (both α-and β-chains) are underway in our laboratory.
openaire   +2 more sources

Complement Components C4A and C4B in Human Lupus

2005
For over half a century low serum complement C4 concentrations have been recognized as a manifestation of systemic lupus erythematosus (SLE). However, the role of C4 in human SLE remains elusive. This is partly because of the unusually complex C4 genetics with frequent variations in gene number, gene size, protein isoforms, and expression levels.
Yan Yang, Erwin K. Chung, Karl Lhotta, Yee Ling Wu, Gloria C. Higgins, Robert M. Rennebohm, Lee A. Hebert, Daniel J. Birmingham, Brad H. Rovin, C. Yung Yu   +9 more
openaire   +1 more source

THE FREQUENCY OF C4B VARIANTS OF COMPLEMENT IN FAMILIAL AND SPORADIC ALZHEIMER DISEASE

Alzheimer Disease & Associated Disorders, 1987
A previous study reported an unexpected increased frequency of the uncommon C4B2 allele of complement in a group of patients with senile dementia of the Alzheimer type. We compared the frequency of various C4B types in 25 patients with familial Alzheimer dementia (AD), 22 patients with sporadic AD, and 360 control individuals.
T D, Bird, M, Boehnke, J, Anderson, T H, Lampe, G, Schellenberg, E B, Larson   +5 more
openaire   +2 more sources

The mechanism of activation of the alternative pathway of complement by cell-bound C4b

Molecular Immunology, 1990
Investigations into the mechanism of alternative pathway-dependent lysis of C4b-coated cells are reported. Test cells (EAC1q4b) were formed by reaction of sheep erythrocytes with antibody, C1 and C4. In C5-deficient serum, more C3b was deposited onto EAC1qC4b than onto control cells (EAC1q).
T C, Farries, K L, Steuer, J P, Atkinson
openaire   +2 more sources

Human receptor for C3b/C4b: Complement receptor type I

1987
Publisher Summary Receptor function and protein are shown to reside on cells of the myelomonocytic series, mature B lymphocytes, glomerular podocytes, a small population of T lymphocytes, follicular dendritic cells, and even in plasma. The purification scheme to be described in the chapter has made available amounts of purified CR1 sufficient for ...
W W, Wong, D T, Fearon
openaire   +2 more sources

Human Complement Components C4A and C4B Genetic Diversities: Complex Genotypes and Phenotypes

Current Protocols in Immunology, 2005
AbstractThis unit describes methods that can accurately determine the genotypes and phenotypes of human complement components C4A and C4B. Specifically, they allow investigators to determine how many C4 genes are present in a diploid genome of a human subject and to quantify how many of them encode C4A proteins and how many of them encode C4B proteins.
Yee Ling Wu
exaly   +3 more sources

Binding of human complement component C4b-binding protein (C4BP) to Streptococcus pyogenes involves the C4b-binding site

The Journal of Immunology, 1996
Abstract A key step in the elimination of invading pathogens from the body is the covalent binding of complement proteins C3b and C4b to their surface. However, many pathogens have evolved mechanisms to avoid the complement system of the host. Understanding how these mechanisms work may lead to more efficacious forms of therapy.
P, Accardo, P, Sánchez-Corral, O, Criado, E, García, S, Rodríguez de Córdoba   +4 more
openaire   +2 more sources

Binding of the complement inhibitor C4b-binding protein to Lyme disease borreliae

Molecular Immunology, 2010
The Lyme disease spirochetes, Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii, are tick-borne pathogens that can cause chronic disseminated infections. To survive in the human host borreliae need to evade the immune system. It is already well known that B. burgdorferi ss. and B.
Johanna, Pietikäinen, Taru, Meri, Anna M, Blom, Seppo, Meri   +3 more
openaire   +2 more sources

Mechanism of activation of the classical pathway of complement by monoclonal IgE (DES). Restricted regulation of C4b by C4b‐binding protein

European Journal of Immunology, 1984
AbstractA human monoclonal IgE from patient DES, IgE (DES), has been shown to activate the classical pathway of complement. The mechanism of this activation has been investigated and can be summarized as follows: (a) IgE (DES) is able to bind and activate C1 in a dose‐dependent fashion.
openaire   +2 more sources

Complement inhibitor C4b-binding protein—friend or foe in the innate immune system?

Molecular Immunology, 2004
The complement system constitutes an important component of the defence against foreign organisms, functioning both in innate and adaptive immune systems. It is potentially harmful also to the own organism and is therefore tightly regulated by a number of membrane-bound and soluble factors.
Anna M, Blom, Bruno O, Villoutreix, Björn, Dahlbäck   +2 more
openaire   +2 more sources