Results 231 to 240 of about 712,823 (260)

Binding of human complement component C4b-binding protein (C4BP) to Streptococcus pyogenes involves the C4b-binding site.

The Journal of Immunology, 1996
Abstract A key step in the elimination of invading pathogens from the body is the covalent binding of complement proteins C3b and C4b to their surface. However, many pathogens have evolved mechanisms to avoid the complement system of the host. Understanding how these mechanisms work may lead to more efficacious forms of therapy.
P, Accardo, P, Sánchez-Corral, O, Criado, E, García, S, Rodríguez de Córdoba   +4 more
openaire   +2 more sources

Targeting C3b/C4b and VEGF with a bispecific fusion protein optimized for neovascular age-related macular degeneration therapy

Science Translational Medicine, 2022
Antiangiogenesis therapies targeting vascular endothelial growth factor (VEGF) have revolutionized the treatment of neovascular ocular diseases, including neovascular age-related macular degeneration (nAMD).
Shiqi Yang, Tong Li, Huixun Jia, Min Gao, Yiming Li, Xiaoling Wan, Zhen Huang, Min Li, Yuanqi Zhai, Xiaomeng Li, Xiaotong Yang, Tao Wang, Jian Liang, Qing Gu, Xueting Luo, L. Qian, Shu-Han Lu, Junjian Liu, Yanping Song, Fenghua Wang, Xiaodong Sun, Dechao Yu   +21 more
semanticscholar   +1 more source

Targeting therapeutic against C3b/C4b, SB002, on the inflammation-induced bone loss in experimental periodontitis.

Journal of Clinical Periodontology, 2023
AIMS To use experimental periodontitis models in rats to investigate the correlation between local expression of complement components C3b and C4b in periodontal tissues and disease severity, and to assess the therapeutic effects of targeting C3b/C4b on ...
Ren-Yeong Huang, Fang-Yi Tseng, Jhong-Jhe You, T. V. Van Dyke, Chia-Dan Cheng, Cheng-En Sung, Pei-Wei Weng, Y. Shieh, Wan-Chien Cheng   +8 more
semanticscholar   +1 more source

Glomerular deposition of the complement C4 isotypes C4A and C4B in glomerulonephritis

Nephrology Dialysis Transplantation, 1996
Complement C4 is a component of the classical complement pathway, which is a major mediator of inflammation in many forms of glomerulonephritis. The two isoforms of C4-C4A and C4B-differ in their physicochemical and functional properties.The glomerular deposition of C4A and C4B was investigated in 39 cases of glomerulonephritis with classical pathway ...
K, Lhotta, A, Schlogl, F, Kronenberg, M, Joannidis, P, Konig   +4 more
openaire   +2 more sources

Human Complement Components C4A and C4B Genetic Diversities: Complex Genotypes and Phenotypes

Current Protocols in Immunology, 2005
AbstractThis unit describes methods that can accurately determine the genotypes and phenotypes of human complement components C4A and C4B. Specifically, they allow investigators to determine how many C4 genes are present in a diploid genome of a human subject and to quantify how many of them encode C4A proteins and how many of them encode C4B proteins.
Erwin K, Chung, Yee Ling, Wu, Yan, Yang, Bi, Zhou, C Yung, Yu   +4 more
openaire   +2 more sources

Binding of the complement inhibitor C4b-binding protein to Lyme disease borreliae

Molecular Immunology, 2010
The Lyme disease spirochetes, Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii, are tick-borne pathogens that can cause chronic disseminated infections. To survive in the human host borreliae need to evade the immune system. It is already well known that B. burgdorferi ss. and B.
Johanna, Pietikäinen, Taru, Meri, Anna M, Blom, Seppo, Meri   +3 more
openaire   +2 more sources

cDNA structure of rabbit C4b-binding protein α-chain. Preserved sequence motive in complement regulatory protein modules which bind C4b

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1995
A full length cDNA clone for the alpha-chain of the rabbit complement regulatory protein C4b-binding protein (C4BP) was isolated from a liver cDNA library. The clone encoded an open reading frame of 597 amino acids, which included a signal peptide, eight short consensus repeats (SCR) and a carboxy terminal non-repeat region.
P, García de Frutos, B, Dahlbäck
openaire   +2 more sources

Complement inhibitor C4b-binding protein—friend or foe in the innate immune system?

Molecular Immunology, 2004
The complement system constitutes an important component of the defence against foreign organisms, functioning both in innate and adaptive immune systems. It is potentially harmful also to the own organism and is therefore tightly regulated by a number of membrane-bound and soluble factors.
Anna M, Blom, Bruno O, Villoutreix, Björn, Dahlbäck   +2 more
openaire   +2 more sources

The Interaction between Anticoagulant Protein S and Complement Regulatory C4b-binding Protein (C4BP)

Trends in Cardiovascular Medicine, 2000
An important mechanism of regulation of blood coagulation is the anticoagulant protein C pathway. In this pathway, the anticoagulant activity of activated protein C is increased by its cofactor protein S. The cofactor activity of protein S can be regulated by binding to complement regulatory C4b-binding protein (C4BP).
van de Poel, R. H., Meijers, J. C., Bouma, B. N.   +2 more
openaire   +2 more sources

Evaluation of Complement-Dependent Cytotoxicity Using ATP Measurement and C1q/C4b Binding

2013
One of the major issues for antibody treatment is enhancement of efficacy. Recent studies have highlighted the important role of effector functions in improvement of antibody therapy. Among effector functions, complement-dependent cytotoxicity (CDC), which induces cell lysis by a cascade of activation triggered by the binding of C1q subunits to the Fc ...
Lucile, Broyer, Liliane, Goetsch, Matthieu, Broussas   +2 more
openaire   +2 more sources