Results 141 to 150 of about 39,430 (282)

Ancestral roles of the classical complement pathway uncovered through functional analysis of factor D-depleted carp serum

Comparative Immunology Reports
The complement system of jawed vertebrates comprises three activation routes—classical (CP), lectin (LP), and alternative (AP) pathways—yet the functional architecture of these cascades in early vertebrates remain insufficiently defined.
Akhil Kizhakkumpat, Michiyo Kimura, Takahiro Nagasawa, Tomonori Somamoto, Miki Nakao   +4 more
doaj   +1 more source

Role of Murine Complement Component C5 in Acute in Vivo Infection by Pathogenic Leptospira interrogans

, 2018
Leptospirosis is considered one of the most important zoonosis worldwide. The activation of the Complement System is important to control dissemination of several pathogens in the host.
Mariane T. Amano, Íris A. de Castro, Lourdes Isaac, Tatiana R. Fraga, Silvio A. Vasconcellos, Ana M. G. da Silva, Lorena Bavia, Leandro C. D. Breda, Adriana P. Granados-Martinez   +8 more
core   +1 more source

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, EarlyView.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source

Complement Component C5 and Graft-Versus-Host-Disease [PDF]

, 2019
Graft versus Host Disease (GvHD) is one of the main complications patients face after receiving a bone marrow transplant. Between 40-60% of bone marrow transplant recipients develop GvHD, with consequent systemic inflammation/fibrosis, reduced quality of
Todorova, Ekaterina
core  

Terminal complement without C5 convertase? [PDF]

Blood, 2021
openaire   +2 more sources

Successive Azide and DNA Functionalization for Reversible and Controlled Association of Single‐Wall Carbon Nanotubes

Chemistry – A European Journal, EarlyView.
A newly synthesized bifunctional azide—diazonium linker allows robust one‐step introduction of azido groups to single‐wall carbon nanotubes. Versatility of the azido groups as reactive handles is demonstrated by further derivatization with 6‐carboxyfluorescein and oligonucleotides.
Razieh Moosavi, Tharun K. Kotammagari, Pia Damlin, Mikko Salomäki, Mika Lastusaari, Han Li, Tuomas Lönnberg   +6 more
wiley   +1 more source

Complement proteins changes in ischemic stroke patients and their relation to outcome

Immunobiology
We studied plasma levels of complement system factors C1q, C2, C3, C3b, C4, C4b, C5, C5a, C9 of 84 patients with ischemic stroke within 24 h from onset of symptoms and on seventh day after admission, using Luminex immunoassay.
Radosław Opiła, Karolina Łuczkowska, Edyta Paczkowska, Przemysław Nowacki, Jarosław Peregud-Pogorzelski, Bogusław Machaliński   +5 more
doaj   +1 more source

Characterizing a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis [PDF]

, 2018
\ua9 2018 The Authors. Immunology Published by John Wiley & Sons Ltd. C5 plays a major role in complement activation; C5 convertase cleaves C5 into the pro-inflammatory C5a, and C5b, the nidus for the formation of the lytic membrane attack complex ...
Morgan BP, Stott M, Walters D, Zelek WM, Harris CL   +4 more
core  

Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus

, 2009
Staphylococcus aureus secretes the SSL7 protein as part of its immune evasion strategy. The protein binds both complement C5 and IgA, yet it is unclear whether SSL7 cross-links these two proteins and, if so, what purpose this serves the pathogen. We have
Fredslund, F, Bjerre, M, Gordon, NL, Hermans, Stefan, Anderssen, G, Wines, B, Jackson, NJH, Christensen, JB, Laursen, NS, Spillner, E, Lorenz, Natalie, Sottrup-Jensen, L, Jensen, M, Fraser, John   +13 more
core   +1 more source

Hybrid machine learning and genetic algorithm approach for catalyst and process optimization in Fischer–Tropsch synthesis toward sustainable fuel production

The Canadian Journal of Chemical Engineering, EarlyView.
Graphical representation of a data‐driven framework for Fischer‐Tropsch synthesis (FTS) modelling and optimization. Abstract This study presents a data‐driven approach for predicting the relationships between catalyst design, process conditions, and product selectivity in Fischer–Tropsch synthesis (FTS).
Doaa M. Hassan, Ryan Gosselin, Nicolas Abatzoglou   +2 more
wiley   +1 more source