Results 161 to 170 of about 68,603 (270)

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

An innovative AQP4 loop C-targeted monoclonal antibody reduces complement-dependent cytotoxicity and lessens experimental neuromyelitis optica

Kaichen Wang, Lan‐Wan Wang, Cheih-Min Chen, Jing-Wun Chen, Gu‐Jiun Lin, Li‐Te Chin, Chih-Fen Hu, Huey‐Kang Sytwu, Shyi-Jou Chen   +8 more
openalex   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Directed-Complement Activation as a Novel Immunotherapeutic Approach for HER2-Breast Cancer

ImmunoTargets and Therapy
Carole Seguin-Devaux,1,* Bianca Brandus,1,* Jean-Marc Plesseria,1 Gilles Iserentant,1 Jean-Yves Servais,1 Aubin Pitiot,1 Georgia Kanli,2 Iris Behrmann,3 Rafaëla Schober,1 Jacques Zimmer,1 Jacques HM Cohen,4 Xavier Dervillez1,3 1Department
Seguin-Devaux C, Brandus B, Plesseria JM, Iserentant G, Servais JY, Pitiot A, Kanli G, Behrmann I, Schober R, Zimmer J, Cohen JH, Dervillez X   +11 more
doaj  

The Fc fragment of soluble IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement-dependent cytotoxicity

Andrea J. Pinto, Chantal Dumestre‐Pérard, Anne Chouquet, Isabelle Bally, Véronique Rosse, Nicole M. Thielens, Wai Li Ling, Renate Kunert, Christine Gaboriaud, Jean‐Baptiste Reiser   +9 more
openalex   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

A novel anti-EGFR monoclonal antibody (EMab-17) exerts antitumor activity against oral squamous cell carcinomas via antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. [PDF]

Oncol Lett, 2020
Takei J, Kaneko MK, Ohishi T, Kawada M, Harada H, Kato Y.   +5 more
europepmc   +1 more source