Results 21 to 30 of about 68,603 (270)

The Contribution of IgG Glycosylation to Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement-Dependent Cytotoxicity (CDC) in Hashimoto's Thyroiditis: An in Vitro Model of Thyroid Autoimmunity. [PDF]

Biomolecules, 2020
Ząbczyńska M, Polak K, Kozłowska K, Sokołowski G, Pocheć E.   +4 more
europepmc   +2 more sources

Complement C3 inhibitory peptide AMY-101 ameliorates brain injury in a mouse model of NMOSD [PDF]

Annals of Medicine
Background Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory demyelinating disease of the central nervous system, clinically characterized primarily by optic neuritis and transverse myelitis. This study aimed to investigate the
Wenli Zhu, Fangping He, Fanxia Meng, Ruili Wei, Hui Liang   +4 more
doaj   +2 more sources

Complement-Dependent Activity of CD20-Specific IgG Correlates With Bivalent Antigen Binding and C1q Binding Strength

Frontiers in Immunology, 2021
Monoclonal antibodies directed against the CD20 surface antigen on B cells are widely used in the therapy of B cell malignancies. Upon administration, the antibodies bind to CD20 expressing B cells and induce their depletion via cell- and complement ...
Sina Bondza, Sina Bondza, Anita Marosan, Sibel Kara, Josephine Lösing, Matthias Peipp, Falk Nimmerjahn, Jos Buijs, Jos Buijs, Anja Lux   +9 more
doaj   +1 more source

Mouse CD38-Specific Heavy Chain Antibodies Inhibit CD38 GDPR-Cyclase Activity and Mediate Cytotoxicity Against Tumor Cells

Frontiers in Immunology, 2021
CD38 is the major NAD+-hydrolyzing ecto-enzyme in most mammals. As a type II transmembrane protein, CD38 is also a promising target for the immunotherapy of multiple myeloma (MM).
Natalie Baum, Marie Eggers, Julia Koenigsdorf, Julia Koenigsdorf, Stephan Menzel, Stephan Menzel, Julia Hambach, Julia Hambach, Tobias Staehler, Ralf Fliegert, Frederike Kulow, Gerhard Adam, Friedrich Haag, Peter Bannas, Friedrich Koch-Nolte   +14 more
doaj   +1 more source

Different IVIG glycoforms affect in vitro inhibition of anti-ganglioside antibody-mediated complement deposition. [PDF]

PLoS ONE, 2014
Intravenous immunoglobulin (IVIG) is the first line treatment for Guillain-Barré syndrome and multifocal motor neuropathy, which are caused by anti-ganglioside antibody-mediated complement-dependent cytotoxicity.
Makoto Sudo, Yoshiki Yamaguchi, Peter J Späth, Kana Matsumoto-Morita, Benjamin K Ong, Nortina Shahrizaila, Nobuhiro Yuki   +6 more
doaj   +1 more source

Harnessing the immunomodulatory effects of exercise to enhance the efficacy of monoclonal antibody therapies against B-cell haematological cancers: a narrative review

Frontiers in Oncology, 2023
Therapeutic monoclonal antibodies (mAbs) are standard care for many B-cell haematological cancers. The modes of action for these mAbs include: induction of cancer cell lysis by activating Fcγ-receptors on innate immune cells; opsonising target cells for ...
Harrison D. Collier-Bain, Frankie F. Brown, Frankie F. Brown, Adam J. Causer, Annabelle Emery, Rebecca Oliver, Rebecca Oliver, Sally Moore, James Murray, James E. Turner, James E. Turner, John P. Campbell   +11 more
doaj   +1 more source

Lack of adalimumab's complement dependent cytotoxicity on human cells expressing complement regulatory proteins [PDF]

Journal of Translational Medicine, 2010
It has been reported that upon binding to membrane TNF (mTNF), adalimumab may activate the complement system, leading to complement dependent cytotoxicity (CDC) of targeted cells. CDC has been implicated in mechanisms of action conferring adalimumab’s efficacy.
Kaymakcalan Z, Salfeld J, Grebe K M
doaj   +2 more sources

Complement Activation in the Treatment of B-Cell Malignancies

Antibodies, 2020
Unconjugated monoclonal antibodies (mAb) have revolutionized the treatment of B-cell malignancies. These targeted drugs can activate innate immune cytotoxicity for therapeutic benefit.
Clive S. Zent, Jonathan J. Pinney, Charles C. Chu, Michael R. Elliott   +3 more
doaj   +1 more source

Complement factor H-derived short consensus repeat 18–20 enhanced complement-dependent cytotoxicity of ofatumumab on chronic lymphocytic leukemia cells

Haematologica, 2013
The antitumor activity of monoclonal antibodies in the treatment of chronic lymphocytic leukemia is mediated mainly by antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity.
Susanne Hörl, Zoltan Banki, Georg Huber, Asim Ejaz, Brigitte Müllauer, Ella Willenbacher, Michael Steurer, Heribert Stoiber   +7 more
doaj   +1 more source

Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity. [PDF]

J Clin Invest, 2015
IgG molecules exert both pro- and antiinflammatory effector functions based on the composition of the fragment crystallizable (Fc) domain glycan. Sialylated IgG Fc domains have antiinflammatory properties that are attributed to their ability to increase the activation threshold of innate effector cells to immune complexes by stimulating the ...
Quast I, Keller CW, Maurer MA, Giddens JP, Tackenberg B, Wang LX, Münz C, Nimmerjahn F, Dalakas MC, Lünemann JD.   +9 more
europepmc   +4 more sources