Autoantibodies against complement factor B in rheumatoid arthritis [PDF]
Frontiers in Immunology, 2023 Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder affecting the joints. Many patients carry anti-citrullinated protein autoantibodies (ACPA).
Alexandra T. Matola +12 more
doaj +4 more sources
Complement factor B knockdown by short hairpin RNA inhibits laser-induced choroidal neovascularization in rats [PDF]
International Journal of Ophthalmology, 2020 AIM: To evaluate whether recombinant complement factor B (CFB) short hairpin RNA (shRNA) reduces laser-induced choroidal neovascularization (CNV) in rats.
Xin Wang +5 more
doaj +2 more sources
Complement factor B activation in patients with preeclampsia. [PDF]
J Reprod Immunol, 2015 Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Bb, the active fragment of complement factor B (fB), has been reported to be a predictor of preeclampsia. However, conflicting results have been found by some investigators.
Velickovic I +17 more
europepmc +4 more sources
Complement factor B mutation-associated aHUS and myocardial infarction. [PDF]
BMJ Case Rep, 2017 A 6-month-old female infant was referred with a 3-day history of low-grade fever, slight nasal congestion and rhinorrhoea. On admission, the clinical findings were unremarkable and she was discharged home. However, she became progressively more listless with a decreased urine output and was once again seen in the emergency department.
Noronha N, Costa FD, Dias A, Dinis A.
europepmc +4 more sources
Complement factor B in high glucose–induced podocyte injury and diabetic kidney disease [PDF]
JCI Insight, 2021 The role and mechanisms for upregulating complement factor B (CFB) expression in podocyte dysfunction in diabetic kidney disease (DKD) are not fully understood. Here, analyzing Gene Expression Omnibus GSE30528 data, we identified genes enriched in mTORC1
Qingmiao Lu +8 more
doaj +2 more sources
Blocking Complement Factor B Activation Reduces Renal Injury and Inflammation in a Rat Brain Death Model [PDF]
Frontiers in Immunology, 2019 Introduction: The majority of kidneys used for transplantation are retrieved from brain-dead organ donors. In brain death, the irreversible loss of brain functions results in hemodynamic instability, hormonal changes and immunological activation ...
Neeltina M. Jager +10 more
doaj +2 more sources
Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury. [PDF]
PLoS ONE, 2017 The pathophysiology of myocardial injury that results from cardiac ischemia and reperfusion (I/R) is incompletely understood. Experimental evidence from murine models indicates that innate immune mechanisms including complement activation via the ...
Nicholas Chun +20 more
doaj +2 more sources
AICAR suppresses TNF-α-induced complement factor B in RPE cells. [PDF]
Sci Rep, 2017 AbstractAge related macular degeneration is the leading cause of blindness in the developed world. Although its precise cause remains elusive, dysfunction of the retinal pigment epithelium (RPE) and dysregulation of complement have been implicated in its pathogenesis.
Chung EJ +6 more
europepmc +5 more sources
Complement profiling for treatment outcomes in pulmonary TB [PDF]
Frontiers in ImmunologyIntroductionThe complement system plays a vital role in the immune response against tuberculosis (TB), aiding in the recognition and clearance of Mycobacterium tuberculosis.
Nathella Pavan Kumar +11 more
doaj +2 more sources
Factor H preserves alternative complement function during ARDS, linked to improved survival
ERJ Open Research, 2023 Background Effective regulation of complement activation may be crucial to preserving complement function during acute respiratory distress syndrome (ARDS). Factor H is the primary negative regulator of the alternative pathway of complement.
William Bain +11 more
doaj +1 more source