Results 1 to 10 of about 1,348,900 (304)

Autoantibodies against complement factor B in rheumatoid arthritis. [PDF]

Front Immunol, 2023
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder affecting the joints. Many patients carry anti-citrullinated protein autoantibodies (ACPA). Overactivation of the complement system seems to be part of the pathogenesis of RA, and autoantibodies against the pathway initiators C1q and MBL, and the regulator of the complement ...
Matola AT, Fülöp A, Rojkovich B, Nagy G, Sármay G, Józsi M, Uzonyi B.   +6 more
europepmc   +5 more sources

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]

PLoS ONE, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
AG Barbour, AG Barbour, AG Barbour, AG Barbour, AS Coleman, C Neeleman, C Siegel, C Skerka, CA Brissette, Christiane Brenner, CS Brooks, D Raoult, David M. Ojcius, DJ Grab, E Rossmann, E Rossmann, GD Wieland, H Fuchs, J Bunikis, JA Gebbia, JC Scott, JC Setubal, JL Coleman, JV McDowell, K Hartmann, KM Hovis, KM Hovis, KO Sundnes, L Houhamdi, Markus M. Simon, MD Kramer, Melanie Schott, MK Pangburn, NM Ras, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Stewart, Peter F. Zipfel, Peter Kraiczy, PF Zipfel, PF Zipfel, PM Southern, RD Horstmann, Reinhard Wallich, S Hammerschmidt, S Kuhn, S Kuhn, S Poltermann, S Ram, Sally J. Cutler, SH Rooijakkers, SJ Cutler, Sonja Grosskinsky, T Meri, T Meri, WR Zuckert   +59 more
core   +29 more sources

Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma [PDF]

The American Journal of Pathology, 2017
Cutaneous squamous cell carcinoma (cSCC) is one of the most common metastatic skin cancers with increasing incidence. We examined the roles of complement component C3 and complement factor B (CFB) in the growth of cSCC. Analysis of cSCC cell lines (n = 8)
Farshchian, Mehdi, Grenman, Reidar, Heljasvaara, Ritva, Kahari, Veli-Matti, Kallajoki, Markku, Kivisaari, Atte, Meri, Seppo, Nissinen, Liisa, Peltonen, Juha, Peltonen, Sirkku, Pihlajaniemi, Taina, Riihila, Pilvi   +11 more
core   +7 more sources

Complement factor B activation in patients with preeclampsia. [PDF]

J Reprod Immunol, 2015
Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Bb, the active fragment of complement factor B (fB), has been reported to be a predictor of preeclampsia. However, conflicting results have been found by some investigators.
Velickovic I, Dalloul M, Wong KA, Bakare O, Schweis F, Garala M, Alam A, Medranda G, Lekovic J, Shuaib W, Tedjasukmana A, Little P, Hanono D, Wijetilaka R, Weedon J, Lin J, Toledano Rd, Zhang M.   +17 more
europepmc   +4 more sources

Complement factor B mutation-associated aHUS and myocardial infarction. [PDF]

BMJ Case Rep, 2017
A 6-month-old female infant was referred with a 3-day history of low-grade fever, slight nasal congestion and rhinorrhoea. On admission, the clinical findings were unremarkable and she was discharged home. However, she became progressively more listless with a decreased urine output and was once again seen in the emergency department.
Noronha N, Costa FD, Dias A, Dinis A.
europepmc   +4 more sources

Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome. [PDF]

Hypertension, 2017
CFB (complement factor B) is elevated in adipose tissue and serum from patients with type 2 diabetes mellitus and cardiovascular disease, but the causal relationship to disease pathogenesis is unclear.
Coan PM, Barrier M, Alfazema N, Carter RN, Marion de Procé S, Dopico XC, Garcia Diaz A, Thomson A, Jackson-Jones LH, Moyon B, Webster Z, Ross D, Moss J, Arends MJ, Morton NM, Aitman TJ.   +15 more
europepmc   +4 more sources

Novel Complement Factor B Gene Mutation Identified in a Kidney Transplant Recipient with a Shiga Toxin-Triggered Episode of Thrombotic Microangiopathy. [PDF]

Am J Case Rep, 2022
Korzycka J, Pawłowicz-Szlarska E, Masajtis-Zagajewska A, Nowicki M.   +3 more
europepmc   +2 more sources

Complement factor B is essential for the proper function of the peripheral auditory system. [PDF]

Front Neurol, 2023
Brown LN, Barth JL, Jafri S, Rumschlag JA, Jenkins TR, Atkinson C, Lang H.   +6 more
europepmc   +3 more sources

Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer. [PDF]

Cell Oncol (Dordr), 2021
Shimazaki R, Takano S, Satoh M, Takada M, Miyahara Y, Sasaki K, Yoshitomi H, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Sogawa K, Motohashi S, Nomura F, Miyazaki M, Ohtsuka M.   +15 more
europepmc   +2 more sources

AICAR suppresses TNF-α-induced complement factor B in RPE cells. [PDF]

Sci Rep, 2017
AbstractAge related macular degeneration is the leading cause of blindness in the developed world. Although its precise cause remains elusive, dysfunction of the retinal pigment epithelium (RPE) and dysregulation of complement have been implicated in its pathogenesis.
Chung EJ, Efstathiou NE, Konstantinou EK, Maidana DE, Miller JW, Young LH, Vavvas DG.   +6 more
europepmc   +5 more sources