Results 1 to 10 of about 367,967 (298)

Autoantibodies against complement factor B in rheumatoid arthritis [PDF]

Frontiers in Immunology, 2023
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder affecting the joints. Many patients carry anti-citrullinated protein autoantibodies (ACPA).
Alexandra T. Matola, Alexandra T. Matola, Angéla Fülöp, Bernadette Rojkovich, György Nagy, György Nagy, György Nagy, György Nagy, Gabriella Sármay, Mihály Józsi, Mihály Józsi, Barbara Uzonyi, Barbara Uzonyi   +12 more
doaj   +4 more sources

Factor B as a therapeutic target for the treatment of complement-mediated diseases

Frontiers in Immunology
The complement system, consisting of three initiating pathways—classical, lectin and alternative, is an important part of innate immunity. Dysregulation of the complement system is implicated in the pathogenesis of several autoimmune and inflammatory ...
David Kavanagh, Jonathan Barratt, Anna Schubart, Nicholas J. A. Webb, Matthias Meier, Fadi Fakhouri   +5 more
doaj   +5 more sources

Complement factor B knockdown by short hairpin RNA inhibits laser-induced choroidal neovascularization in rats [PDF]

International Journal of Ophthalmology, 2020
AIM: To evaluate whether recombinant complement factor B (CFB) short hairpin RNA (shRNA) reduces laser-induced choroidal neovascularization (CNV) in rats.
Xin Wang, Qing-Li Shang, Jing-Xue Ma, Shu-Xia Liu, Cai-Xia Wang, Cheng Ma   +5 more
doaj   +2 more sources

Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production [PDF]

Frontiers in Immunology, 2019
Complement factor H (CFH) has a pivotal role in regulating alternative complement activation through its ability to inhibit the cleavage of the central complement component C3, which links innate and humoral immunity.
Máté G. Kiss, Máté G. Kiss, Mária Ozsvár-Kozma, Mária Ozsvár-Kozma, Florentina Porsch, Florentina Porsch, Laura Göderle, Laura Göderle, Nikolina Papac-Miličević, Nikolina Papac-Miličević, Barbara Bartolini-Gritti, Barbara Bartolini-Gritti, Dimitrios Tsiantoulas, Dimitrios Tsiantoulas, Matthew C. Pickering, Christoph J. Binder, Christoph J. Binder   +16 more
doaj   +2 more sources

Complement factor B in high glucose–induced podocyte injury and diabetic kidney disease [PDF]

JCI Insight, 2021
The role and mechanisms for upregulating complement factor B (CFB) expression in podocyte dysfunction in diabetic kidney disease (DKD) are not fully understood. Here, analyzing Gene Expression Omnibus GSE30528 data, we identified genes enriched in mTORC1
Qingmiao Lu, Qing Hou, Kai Cao, Xiaoli Sun, Yan Liang, Mengru Gu, Xian Xue, Allan Zijian Zhao, Chunsun Dai   +8 more
doaj   +2 more sources

Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody. [PDF]

PLoS ONE, 2017
Rituximab therapy for B cell chronic lymphocytic leukemia (B-CLL) has met with mixed success. Among several factors to which resistance can be attributed is failure to activate complement dependent cytotoxicity (CDC) due to protective complement ...
Mark T Winkler, Ryan T Bushey, Elizabeth B Gottlin, Michael J Campa, Eross S Guadalupe, Alicia D Volkheimer, J Brice Weinberg, Edward F Patz   +7 more
doaj   +3 more sources

Blocking Complement Factor B Activation Reduces Renal Injury and Inflammation in a Rat Brain Death Model [PDF]

Frontiers in Immunology, 2019
Introduction: The majority of kidneys used for transplantation are retrieved from brain-dead organ donors. In brain death, the irreversible loss of brain functions results in hemodynamic instability, hormonal changes and immunological activation ...
Neeltina M. Jager, Judith E. van Zanden, Marta Subías, Marta Subías, Henri G. D. Leuvenink, Mohamed R. Daha, Mohamed R. Daha, Santiago Rodríguez de Córdoba, Santiago Rodríguez de Córdoba, Felix Poppelaars, Marc A. Seelen   +10 more
doaj   +2 more sources

Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury. [PDF]

PLoS ONE, 2017
The pathophysiology of myocardial injury that results from cardiac ischemia and reperfusion (I/R) is incompletely understood. Experimental evidence from murine models indicates that innate immune mechanisms including complement activation via the ...
Nicholas Chun, Ala S Haddadin, Junying Liu, Yunfang Hou, Karen A Wong, Daniel Lee, Julie I Rushbrook, Karan Gulaya, Roberta Hines, Tamika Hollis, Beatriz Nistal Nuno, Abeel A Mangi, Sabet Hashim, Marcela Pekna, Amy Catalfamo, Hsiao-Ying Chin, Foramben Patel, Sravani Rayala, Ketan Shevde, Peter S Heeger, Ming Zhang   +20 more
doaj   +2 more sources

The prognostic value of plasma complement factor B (CFB) in thyroid carcinoma. [PDF]

Bioengineered, 2021
Wu P, Shi J, Sun W, Zhang H.
europepmc   +3 more sources

Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis. [PDF]

Gut, 2023
Akhlaghpour M, Haritunians T, More SK, Thomas LS, Stamps DT, Dube S, Li D, Yang S, Landers CJ, Mengesha E, Hamade H, Murali R, Potdar AA, Wolf AJ, Botwin GJ, Khrom M, International IBD Genetics Consortium, Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Sartor RB, Xavier RJ, Brant SR, Cho JH, Duerr RH, Lazarev MG, Rioux JD, Schumm LP, Silverberg MS, Zaghiyan K, Fleshner P, Melmed GY, Vasiliauskas EA, Ha C, Rabizadeh S, Syal G, Bonthala NN, Ziring DA, Targan SR, Long MD, McGovern DPB, Michelsen KS.   +44 more
europepmc   +3 more sources