Results 1 to 10 of about 2,034,857 (344)

Autoantibodies against complement factor B in rheumatoid arthritis [PDF]

Frontiers in Immunology, 2023
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder affecting the joints. Many patients carry anti-citrullinated protein autoantibodies (ACPA).
Alexandra T. Matola, Alexandra T. Matola, Angéla Fülöp, Bernadette Rojkovich, György Nagy, György Nagy, György Nagy, György Nagy, Gabriella Sármay, Mihály Józsi, Mihály Józsi, Barbara Uzonyi, Barbara Uzonyi   +12 more
doaj   +4 more sources

Complement factor B in high glucose–induced podocyte injury and diabetic kidney disease [PDF]

JCI Insight, 2021
The role and mechanisms for upregulating complement factor B (CFB) expression in podocyte dysfunction in diabetic kidney disease (DKD) are not fully understood. Here, analyzing Gene Expression Omnibus GSE30528 data, we identified genes enriched in mTORC1
Qingmiao Lu, Qing Hou, Kai Cao, Xiaoli Sun, Yan Liang, Mengru Gu, Xian Xue, Allan Zijian Zhao, Chunsun Dai   +8 more
doaj   +3 more sources

Complement factor B activation in patients with preeclampsia. [PDF]

J Reprod Immunol, 2015
Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. Bb, the active fragment of complement factor B (fB), has been reported to be a predictor of preeclampsia. However, conflicting results have been found by some investigators.
Velickovic I, Dalloul M, Wong KA, Bakare O, Schweis F, Garala M, Alam A, Medranda G, Lekovic J, Shuaib W, Tedjasukmana A, Little P, Hanono D, Wijetilaka R, Weedon J, Lin J, Toledano Rd, Zhang M.   +17 more
europepmc   +6 more sources

Blocking Complement Factor B Activation Reduces Renal Injury and Inflammation in a Rat Brain Death Model [PDF]

Frontiers in Immunology, 2019
Introduction: The majority of kidneys used for transplantation are retrieved from brain-dead organ donors. In brain death, the irreversible loss of brain functions results in hemodynamic instability, hormonal changes and immunological activation ...
Neeltina M. Jager, Judith E. van Zanden, Marta Subías, Marta Subías, Henri G. D. Leuvenink, Mohamed R. Daha, Mohamed R. Daha, Santiago Rodríguez de Córdoba, Santiago Rodríguez de Córdoba, Felix Poppelaars, Marc A. Seelen   +10 more
doaj   +3 more sources

Associations of complement factor B and complement component 2 genotypes with subtypes of polypoidal choroidal vasculopathy. [PDF]

BMC Ophthalmol, 2014
We previously reported on subtypes of polypoidal choroidal vasculopathy (PCV), and categorized PCV as polypoidal choroidal neovascularization (CNV) and typical PCV. The aim of this study was to clarify whether complement component 2 (C2) and complement factor B (CFB) genotypes are associated with subtypes of polypoidal choroidal vasculopathy, such as ...
Tanaka K, Nakayama T, Mori R, Sato N, Kawamura A, Yuzawa M.   +5 more
europepmc   +6 more sources

Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer. [PDF]

Cell Oncol (Dordr), 2021
The interplay between cancer cells and stromal components, including soluble mediators released from cancer cells, contributes to the progression of pancreatic ductal adenocarcinoma (PDAC).
Shimazaki R, Takano S, Satoh M, Takada M, Miyahara Y, Sasaki K, Yoshitomi H, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Sogawa K, Motohashi S, Nomura F, Miyazaki M, Ohtsuka M.   +15 more
europepmc   +2 more sources

Factor B as a therapeutic target for the treatment of complement-mediated diseases [PDF]

Frontiers in Immunology
The complement system, consisting of three initiating pathways—classical, lectin and alternative, is an important part of innate immunity. Dysregulation of the complement system is implicated in the pathogenesis of several autoimmune and inflammatory ...
David Kavanagh, Jonathan Barratt, Anna Schubart, Nicholas J. A. Webb, Matthias Meier, Fadi Fakhouri   +5 more
doaj   +3 more sources

Complement factor B knockdown by short hairpin RNA inhibits laser-induced choroidal neovascularization in rats [PDF]

International Journal of Ophthalmology, 2020
AIM: To evaluate whether recombinant complement factor B (CFB) short hairpin RNA (shRNA) reduces laser-induced choroidal neovascularization (CNV) in rats.
Xin Wang, Qing-Li Shang, Jing-Xue Ma, Shu-Xia Liu, Cai-Xia Wang, Cheng Ma   +5 more
doaj   +2 more sources

Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome. [PDF]

Hypertension, 2017
CFB (complement factor B) is elevated in adipose tissue and serum from patients with type 2 diabetes mellitus and cardiovascular disease, but the causal relationship to disease pathogenesis is unclear.
Coan PM, Barrier M, Alfazema N, Carter RN, Marion de Procé S, Dopico XC, Garcia Diaz A, Thomson A, Jackson-Jones LH, Moyon B, Webster Z, Ross D, Moss J, Arends MJ, Morton NM, Aitman TJ.   +15 more
europepmc   +2 more sources

AICAR suppresses TNF-α-induced complement factor B in RPE cells. [PDF]

Sci Rep, 2017
Age related macular degeneration is the leading cause of blindness in the developed world. Although its precise cause remains elusive, dysfunction of the retinal pigment epithelium (RPE) and dysregulation of complement have been implicated in its ...
Chung EJ, Efstathiou NE, Konstantinou EK, Maidana DE, Miller JW, Young LH, Vavvas DG.   +6 more
europepmc   +2 more sources