Results 91 to 100 of about 2,568,874 (328)

Characteristics and management of thrombotic microangiopathy in kidney transplantation

Korean Journal of Transplantation, 2023
Thrombotic microangiopathy is not a rare complication of kidney transplantation and is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury with extensive thrombosis of the arterioles and capillaries.
Wonyong Cho, Sang-Kyung Jo, Cheol Woong Jung, Myung-Gyu Kim   +3 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Relax, no need to round: integrality of clustering formulations [PDF]

, 2015
We study exact recovery conditions for convex relaxations of point cloud clustering problems, focusing on two of the most common optimization problems for unsupervised clustering: $k$-means and $k$-median clustering.
Awasthi, Pranjal, Bandeira, Afonso S., Charikar, Moses, Krishnaswamy, Ravishankar, Villar, Soledad, Ward, Rachel   +5 more
core   +2 more sources

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome [PDF]

, 2010
Thrombotic microangiopathies (TMAs) are pathological conditions characterized by generalized microvascular occlusion by platelet thrombi, thrombocytopenia, and microangiopathic hemolytic anemia.
Mastroianni Kirsztajn, Gianna, Polito, Maria Goretti   +1 more
core   +2 more sources

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Mammalian DNA Is an Endogenous Danger Signal That Stimulates Local Synthesis and Release of Complement Factor B

Molecular Medicine, 2012
Complement factor B plays a critical role in ischemic tissue injury and autoimmunity. Factor B is dynamically synthesized and released by cells outside of the liver, but the molecules that trigger local factor B synthesis and release during endogenous ...
D. Kaczorowski, M. Scott, John P Pibris, A. Afrazi, A. Nakao, Rebecca D. Edmonds, Sodam Kim, J. Kwak, Yujian Liu, Jie Fan, T. Billiar   +10 more
semanticscholar   +1 more source

Polymorphisms in ARMS2/HTRA1 and complement genes and age-related macular degeneration in India: findings from the INDEYE study. [PDF]

, 2012
PURPOSE: Association between genetic variants in complement factor H (CFH), factor B (CFB), component 2 (C2), and in the ARMS2/HTRA1 region with age-related macular degeneration (AMD) comes mainly from studies of European ancestry and case-control ...
Chakravarthy, Usha, Fletcher, Astrid E, Nitsch, Dorothea, Nonyane, Bareng AS, Ravindran, Ravilla D, Shanker, Ashwini, Smeeth, Liam, Sundaresan, Periasamy, Vashist, Praveen   +8 more
core   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Exploring the Unitarity Triangle through CP violation observables in $B_s \to K^+ K^-$

, 2004
We discuss the determination of the CKM parameters from the forthcoming $CP$ violation observables in $B_s \to K^+ K^-$ decays. Combining the information on mixing induced CP violation in $B_s \to K^+ K^-$, with the $B_d \to J/\psi K_s$ precision ...
, A. Ali, A. Ali, A. Salim Safir, A.J. Buras, A.K. Giri, A.S. Dighe, A.S. Safir, BaBar collaboration, CKMfitter Group collaboration, D. London, D. Melikhov, F.J. Botella, G. Buchalla, H. Jawahery, Heavy Flavor Averaging Group, I. Dunietz, J. Charles, J.P. Silva, L. Lavoura, M. Beneke, M. Gronau, M. Gronau, M. Kobayashi, N. Cabibbo, P. Ball, P. Ball, P. Ball, R. Fleischer, R. Fleischer, Y. Grossman   +30 more
core   +1 more source