Results 171 to 180 of about 1,348,900 (304)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

POS-759 Atypical hemolytic uremic syndrome with Gain-of-function mutation in complement factor B

, 2022
A. JEMAL, S. Aloui, I. Handous, M. Ben Salem, A. Ltaeif, M. Hamoude, H. Skhiri, M. Ben Salah   +7 more
openalex   +1 more source

Host immune responses to mono-infections ofPlasmodiumspp., hepatitis B virus, andMycobacterium tuberculosisas evidenced by blood complement 3, complement 5, tumor necrosis factor-α and interleukin-10

, 2018
Mathew Folaranmi Olaniyan, Tolulope Busayo Ojediran, Ferdinand Uwaifo, MufutauMosunmade Azeez   +3 more
openalex   +1 more source

A new TaqI polymorphism of the complement factor B gene [PDF]

Nucleic Acids Research, 1988
J M, Lobaccaro, N, Ghanem, C, Sultan, G, Lefranc   +3 more
openaire   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Sodium butyrate blocks interferon-gamma (IFN-γ)-induced biosynthesis of MHC class III gene products (complement C4 and factor B) in human fetal intestinal epithelial cells

, 1999
Kenji Kitamura, Akira Andoh, Taiki Inoue, Y Amakata, Keiko Hodohara, Yoshihide Fujiyama, T Bamba   +6 more
openalex   +1 more source

Predictive value of the complement factors B and H for women with gestational diabetes mellitus who are at risk of preeclampsia

, 2022
Yuting Xue, Nan Yang, Lijuan Ma, Xunke Gu, Keke Jia   +4 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome. [PDF]

Kidney Int, 2020
Zhang Y, Kremsdorf RA, Sperati CJ, Henriksen KJ, Mori M, Goodfellow RX, Pitcher GR, Benson CL, Borsa NG, Taylor RP, Nester CM, Smith RJH.   +11 more
europepmc   +1 more source