Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity. [PDF]
PLoS ONE, 2009 Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Sonja Grosskinsky +7 more
doaj +24 more sources
Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. [PDF]
PLoS ONE, 2013 Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Jasmin Schwab +7 more
doaj +5 more sources
The Bb fragment of complement factor B acts as a B cell growth factor [PDF]
The Journal of experimental medicine, 1988 The process of B cell growth and differentiation into plasma cells is highly regulated and may be influenced by a large number of inflammatory mediators, including complement components.
Marion G. Peters +3 more
semanticscholar +6 more sources
Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production [PDF]
Frontiers in Immunology, 2019 Complement factor H (CFH) has a pivotal role in regulating alternative complement activation through its ability to inhibit the cleavage of the central complement component C3, which links innate and humoral immunity.
Máté G. Kiss +16 more
doaj +2 more sources
Deficiency in complement factor B.
New England Journal of Medicine, 2013 A genetic deficiency of factor B confirms the role of the protein in the activation of the alternative complement pathway in humans and in protection against infection by encapsulated bacteria.
C. Slade +5 more
semanticscholar +3 more sources
Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma [PDF]
The American Journal of Pathology, 2017 Cutaneous squamous cell carcinoma (cSCC) is one of the most common metastatic skin cancers with increasing incidence. We examined the roles of complement component C3 and complement factor B (CFB) in the growth of cSCC. Analysis of cSCC cell lines (n = 8) and normal human epidermal keratinocytes (n = 11) with real-time quantitative PCR and Western ...
Markku Kallajoki +17 more
openaire +8 more sources
Complement activation by whole endotoxin is blocked by a monoclonal antibody to factor B [PDF]
Critical Care Medicine, 1994 Sepsis is both a common and, despite present-day therapy, a serious disease. The pathophysiology of the septic response is a complex, multifactorial phenomenon which in part involves the activation of complement by bacterial endotoxin. A monoclonal antibody to human complement factor B, code-named 1H5, which was capable of specifically inhibiting the ...
Christopher Clardy
openalex +4 more sources
Adipose tissue complement factor B promotes adipocyte maturation. [PDF]
Biochemical and Biophysical Research Communications, 2018 It is well-known that the complement system plays an essential role in host immunity. Observational studies have indicated that complement system-related molecules such as complement factor B (CfB) and other components are correlated with obesity and/or insulin resistance parameters.
Hiroaki Matsunaga +9 more
semanticscholar +3 more sources
Associations of complement factor B and complement component 2 genotypes with subtypes of polypoidal choroidal vasculopathy. [PDF]
BMC Ophthalmol, 2014 BackgroundWe previously reported on subtypes of polypoidal choroidal vasculopathy (PCV), and categorized PCV as polypoidal choroidal neovascularization (CNV) and typical PCV.
Tanaka K +5 more
europepmc +2 more sources
Functional Evaluation of AMD-Associated Risk Variants of Complement Factor B. [PDF]
Invest Ophthalmol Vis Sci, 2020 The 32W and 32Q variants of complement factor B (CFB) are associated with reduced risk of developing neovascular age-related macular degeneration (AMD) compared with the common 32R allele. The objective of this study was to determine if the most protective R32Q variant affects the neovascular process in a manner consistent with the reported reduced ...
Pilotti C, Greenwood J, Moss SE.
europepmc +5 more sources