Results 11 to 20 of about 1,344,365 (268)

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. [PDF]

PLoS ONE, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Jasmin Schwab, Claudia Hammerschmidt, Dania Richter, Christine Skerka, Franz-Rainer Matuschka, Reinhard Wallich, Peter F Zipfel, Peter Kraiczy   +7 more
doaj   +29 more sources

Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma [PDF]

The American Journal of Pathology, 2017
Cutaneous squamous cell carcinoma (cSCC) is one of the most common metastatic skin cancers with increasing incidence. We examined the roles of complement component C3 and complement factor B (CFB) in the growth of cSCC. Analysis of cSCC cell lines (n = 8) and normal human epidermal keratinocytes (n = 11) with real-time quantitative PCR and Western ...
Riihilä, P. (Pilvi), Nissinen, L. (Liisa), Farshchian, M. (Mehdi), Kallajoki, M. (Markku), Kivisaari, A. (Atte), Meri, S. (Seppo), Grénman, R. (Reidar), Peltonen, S. (Sirkku), Peltonen, J. (Juha), Pihlajaniemi, T. (Taina), Heljasvaara, R. (Ritva), Kähäri, V.-M. (Veli-Matti)   +11 more
openaire   +7 more sources

Contribution of the Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (ErpC) to Complement Resistance of Borrelia burgdorferi [PDF]

Clinical and Developmental Immunology, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Claudia Hammerschmidt, Teresia Hallström, Christine Skerka, Reinhard Wallich, Brian Stevenson, Peter F. Zipfel, Peter Kraiczy   +6 more
doaj   +4 more sources

Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome. [PDF]

Hypertension, 2017
CFB (complement factor B) is elevated in adipose tissue and serum from patients with type 2 diabetes mellitus and cardiovascular disease, but the causal relationship to disease pathogenesis is unclear.
Coan PM, Barrier M, Alfazema N, Carter RN, Marion de Procé S, Dopico XC, Garcia Diaz A, Thomson A, Jackson-Jones LH, Moyon B, Webster Z, Ross D, Moss J, Arends MJ, Morton NM, Aitman TJ.   +15 more
europepmc   +4 more sources

Hypoglycemia-induced changes in complement pathways in type 2 diabetes

Atherosclerosis Plus, 2021
Background and aims: An association between hypoglycaemia and adverse cardiovascular events has been suggested from longitudinal and retrospective cohort studies. The complement pathway proteins in hypoglycemia are not well studied. Here, we hypothesized
Abu Saleh Md Moin, Manjula Nandakumar, Ilhame Diboun, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. Butler   +6 more
doaj   +1 more source

THE ROLE OF HUMAN COMPLEMENT PROTEIN FACTOR B AND FACTORP/PROPERDIN IN HIV-ASSOCIATED PRE-ECLAMPSIA

Hypertension in Pregnancy, 2022
Objectives This study seeks to discover how the concentration of complement proteins, factors B and P are affected in HIV-associated PE. Methods This study included 72 pregnant women: 36 preeclamptic and 36 normotensive. Serum concentrations of factors B
Phumelele Kikine, Yazira Pillay, Thajasvarie Naicker   +2 more
doaj   +1 more source

The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure

Frontiers in Immunology, 2021
ObjectiveDysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase C3bBbP are elevated in these ...
Margrethe Flesvig Holt, Margrethe Flesvig Holt, Annika E. Michelsen, Annika E. Michelsen, Negar Shahini, Elisabeth Bjørkelund, Christina Holt Bendz, Richard J. Massey, Richard J. Massey, Camilla Schjalm, Bente Halvorsen, Bente Halvorsen, Kaspar Broch, Kaspar Broch, Thor Ueland, Thor Ueland, Thor Ueland, Lars Gullestad, Lars Gullestad, Lars Gullestad, Per H. Nilsson, Per H. Nilsson, Pål Aukrust, Pål Aukrust, Pål Aukrust, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Mieke C. Louwe   +29 more
doaj   +1 more source

A new complement factor B mutation associated with crescentic C3 glomerulopathy; a case report [PDF]

Journal of Nephropathology, 2019
Background: C3 glomerulopathy is a recently described entity classified as complementassociated glomerular disease. Case Presentation: We report a case of a 48-year-old man referred to the nephrology department for nephrotic syndrome with rapidly ...
Sofia Semedo Coelho, Ana Raquel Fernandes, Elsa Soares, Patrícia Valério, Bruno Matos, Helena Romão, Mário Góis, Helena Sousa, Teresa Fidalgo, Ana Sofia Natário, Carlos Barreto   +10 more
doaj   +1 more source

Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients

Cells, 2023
Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler, Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin   +3 more
doaj   +1 more source

Adipose tissue complement factor B promotes adipocyte maturation [PDF]

Biochemical and Biophysical Research Communications, 2018
It is well-known that the complement system plays an essential role in host immunity. Observational studies have indicated that complement system-related molecules such as complement factor B (CfB) and other components are correlated with obesity and/or insulin resistance parameters.
Hiroaki Matsunaga, Misaki Iwashita, Takanori Shinjo, Akiko Yamashita, Mitsudai Tsuruta, Shoichiro Nagasaka, Ataru Taniguchi, Mitsuo Fukushima, Naoya Watanabe, Fusanori Nishimura   +9 more
openaire   +2 more sources