Complement Factor B Production in Renal Tubular Cells and Its Role in Sodium Transporter Expression During Polymicrobial Sepsis. [PDF]
Crit Care Med, 2016 Objectives:Toll-like receptors and complement are two components of the innate immunity. Complement factor B is essential for the alternative pathway of complement activation.
Li D +8 more
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Splenic RNA and MicroRNA Mimics Promote Complement Factor B Production and Alternative Pathway Activation via Innate Immune Signaling. [PDF]
J Immunol, 2016 Complement factor B (cfB) is an essential component of the alternative pathway (AP) and plays an important role in the pathogenesis of polymicrobial sepsis.
Zou L, Feng Y, Xu G, Jian W, Chao W.
europepmc +2 more sources
The Bb fragment of complement factor B acts as a B cell growth factor. [PDF]
The Journal of experimental medicine, 1988 The process of B cell growth and differentiation into plasma cells is highly regulated and may be influenced by a large number of inflammatory mediators, including complement components. We have studied the regulatory influence of Bb, a 60-kD peptide created during the cleavage of complement Factor B by Factor D and C3b. Purified Bb alone had no effect
Peters, MG +3 more
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Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production [PDF]
Frontiers in Immunology, 2019 Complement factor H (CFH) has a pivotal role in regulating alternative complement activation through its ability to inhibit the cleavage of the central complement component C3, which links innate and humoral immunity.
Máté G. Kiss +16 more
doaj +2 more sources
Deficiency in Complement Factor B
New England Journal of Medicine, 2013 A genetic deficiency of factor B confirms the role of the protein in the activation of the alternative complement pathway in humans and in protection against infection by encapsulated bacteria.
Charlotte Slade +5 more
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Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2006 Hemolytic uremic syndrome (HUS) is an important cause of acute renal failure in children. Mutations in one or more genes encoding complement-regulatory proteins have been reported in approximately one-third of nondiarrheal, atypical HUS (aHUS) patients ...
Elena Goicoechea de Jorge +9 more
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Adipose tissue complement factor B promotes adipocyte maturation [PDF]
Biochemical and Biophysical Research Communications, 2018 It is well-known that the complement system plays an essential role in host immunity. Observational studies have indicated that complement system-related molecules such as complement factor B (CfB) and other components are correlated with obesity and/or insulin resistance parameters.
Hiroaki Matsunaga +9 more
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COMPLEMENT ACTIVATION BY WHOLE ENDOTOXIN IS BLOCKED BY A MONOCLONAL ANTIBODY TO FACTOR B [PDF]
Critical Care Medicine, 1994 Sepsis is both a common and, despite present-day therapy, a serious disease. The pathophysiology of the septic response is a complex, multifactorial phenomenon which in part involves the activation of complement by bacterial endotoxin. A monoclonal antibody to human complement factor B, code-named 1H5, which was capable of specifically inhibiting the ...
Christopher Clardy
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Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration [PDF]
Human Molecular Genetics, 2007 Age-related macular degeneration (AMD) is a devastating disorder of the central retina, causing significant visual impairment for 7.5 million elderly Americans.
Kylee L. Spencer +9 more
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Complement factor B mutations in atypical hemolytic uremic syndrome-disease-relevant or benign?
J Am Soc Nephrol, 2014 Atypical hemolytic uremic syndrome (aHUS) is a genetic ultrarare renal disease associated with overactivation of the alternative pathway of complement.
Marinozzi MC +15 more
europepmc +2 more sources