Results 21 to 30 of about 2,034,857 (344)

Complement Factor B Gene Regulation: Synergistic Effects of TNF-α and IFN-γ in Macrophages [PDF]

Journal of Immunology, 2002
Complement factor B (Bf) plays an important role in activating the alternative complement pathway. The inflammatory cytokines, in particular TNF-α and IFN-γ, are critical in the regulation of Bf gene expression in macrophages.
Yong Huang, Peter M. Krein, Daniel A. Muruve, Brent W. Winston   +3 more
openalex   +2 more sources

Functional Evaluation of AMD-Associated Risk Variants of Complement Factor B. [PDF]

Invest Ophthalmol Vis Sci, 2020
The 32W and 32Q variants of complement factor B (CFB) are associated with reduced risk of developing neovascular age-related macular degeneration (AMD) compared with the common 32R allele. The objective of this study was to determine if the most protective R32Q variant affects the neovascular process in a manner consistent with the reported reduced ...
Pilotti C, Greenwood J, Moss SE.
europepmc   +5 more sources

Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody. [PDF]

PLoS ONE, 2017
Rituximab therapy for B cell chronic lymphocytic leukemia (B-CLL) has met with mixed success. Among several factors to which resistance can be attributed is failure to activate complement dependent cytotoxicity (CDC) due to protective complement ...
Mark T Winkler, Ryan T Bushey, Elizabeth B Gottlin, Michael J Campa, Eross S Guadalupe, Alicia D Volkheimer, J Brice Weinberg, Edward F Patz   +7 more
doaj   +3 more sources

Access to the Complement Factor B Scissile Bond Is Facilitated by Association of Factor B with C3b Protein [PDF]

Journal of Biological Chemistry, 2011
Factor B is a zymogen that carries the catalytic site of the complement alternative pathway C3 convertase. During convertase assembly, factor B associates with C3b and Mg(2+) forming a pro-convertase C3bB(Mg(2+)) that is cleaved at a single factor B site by factor D. In free factor B, a pair of salt bridges binds the Arg(234) side chain to Glu(446) and
Dennis E. Hourcade, Lynne M. Mitchell
openaire   +3 more sources

Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis [PDF]

Biomedicines
Background: Membranoproliferative glomerulonephritis (MPGN) is an umbrella term for chronic disorders affecting the glomeruli. MPGN is often accompanied by the presence of autoantibodies against complement components.
Alexandra T. Matola, Dorottya Csuka, Ágnes Szilágyi, Michael Rudnicki, Zoltán Prohászka, Mihály Józsi, Barbara Uzonyi   +6 more
doaj   +2 more sources

Complement factor B mutation-associated aHUS and myocardial infarction. [PDF]

BMJ Case Rep, 2017
A 6-month-old female infant was referred with a 3-day history of low-grade fever, slight nasal congestion and rhinorrhoea. On admission, the clinical findings were unremarkable and she was discharged home. However, she became progressively more listless with a decreased urine output and was once again seen in the emergency department.
Noronha N, Costa FD, Dias A, Dinis A.
europepmc   +5 more sources

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Complement is a key component of the innate immune system; however, its dysregulation due to genetic mutations or the presence of autoantibodies can cause a number of diseases including age-related macular degeneration, paroxysmal nocturnal ...
Anna Schubart, Karen Anderson, Nello Mainolfi, Holger Sellner, Takeru Ehara, Christopher M. Adams, A. Mac Sweeney, Sha-Mei Liao, Maura Crowley, Amanda Littlewood‐Evans, Sophie Sarret, Grazyna Wieczorek, Ludovic Perrot, Valérie Dubost, Thierry Flandre, Yuzhou Zhang, Richard J. Smith, Antonio M. Risitano, Rajeshri G. Karki, Chun Zhang, Eric Valeur, Finton Sirockin, Bernd Gerhartz, P. Erbel, Nicola Hughes, Thomas M. Smith, Frédéric Cumin, Upendra A. Argikar, Börje Haraldsson, Muneto Mogi, Richard Sedrani, Christian Wiesmann, Bruce Jaffee, Jürgen Maibaum, Stefanie Flohr, R. A. Harrison, Jörg Eder   +36 more
openalex   +2 more sources

Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury. [PDF]

PLoS ONE, 2017
The pathophysiology of myocardial injury that results from cardiac ischemia and reperfusion (I/R) is incompletely understood. Experimental evidence from murine models indicates that innate immune mechanisms including complement activation via the ...
Nicholas Chun, Ala S Haddadin, Junying Liu, Yunfang Hou, Karen A Wong, Daniel Lee, Julie I Rushbrook, Karan Gulaya, Roberta Hines, Tamika Hollis, Beatriz Nistal Nuno, Abeel A Mangi, Sabet Hashim, Marcela Pekna, Amy Catalfamo, Hsiao-Ying Chin, Foramben Patel, Sravani Rayala, Ketan Shevde, Peter S Heeger, Ming Zhang   +20 more
doaj   +2 more sources

The prognostic value of plasma complement factor B (CFB) in thyroid carcinoma. [PDF]

Bioengineered, 2021
Wu P, Shi J, Sun W, Zhang H.
europepmc   +3 more sources

Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis. [PDF]

Gut, 2023
Akhlaghpour M, Haritunians T, More SK, Thomas LS, Stamps DT, Dube S, Li D, Yang S, Landers CJ, Mengesha E, Hamade H, Murali R, Potdar AA, Wolf AJ, Botwin GJ, Khrom M, International IBD Genetics Consortium, Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Sartor RB, Xavier RJ, Brant SR, Cho JH, Duerr RH, Lazarev MG, Rioux JD, Schumm LP, Silverberg MS, Zaghiyan K, Fleshner P, Melmed GY, Vasiliauskas EA, Ha C, Rabizadeh S, Syal G, Bonthala NN, Ziring DA, Targan SR, Long MD, McGovern DPB, Michelsen KS.   +44 more
europepmc   +3 more sources