Results 291 to 300 of about 2,034,857 (344)

Cloning and sequencing of the porcine complement factor B

Immunogenetics, 1991
A genomic clone, SSBf1, containing the complement factor B (BF), a major histocompatibility class III antigen, has been isolated from a porcine genomic library. Partial sequencing and comparison with a human BF gene has identified seven exons coding for amino acids of Ba and Bb, the two subunits of BF.
Alex Van De Weghe, Alex Van Zeveren, Yves Bouquet, Luc Peelman, Wouter Coppieters   +4 more
openaire   +3 more sources

Reference Typing Report for Complement Factor B

Experimental and Clinical Immunogenetics, 1998
Factor B (BF) reference typing was carried out on the occasion of the VIIth Complement Genetics Workshop in Mainz, May 1998. Two different sets of samples were analysed by agarose electrophoresis and/or isoelectric focusing at the protein level, and by PCR-RFLP analysis at the DNA level.
Beate Stradmann-Bellinghausen, P. Otremba, Peter M. Schneider, Gunther Geserick, H. Schröder   +4 more
openaire   +2 more sources

Identification of human complement factor B as a novel biomarker candidate for pancreatic ductal adenocarcinoma.

Journal of Proteome Research, 2014
Pancreatic cancer (PC; pancreatic ductal adenocarcinoma) is characterized by significant morbidity and mortality worldwide. Although carbohydrate antigen (CA) 19-9 has been known as a PC biomarker, it is not commonly used for general screening because of
Min Jung Lee, Keun Na, Seul‐Ki Jeong, Jong-Sun Lim, S. Kim, Min‐Ji Lee, S. Song, Hoguen Kim, W. Hancock, Y. Paik   +9 more
semanticscholar   +1 more source

Molecular Basis for the Microheterogeneity of Human Complement Factor B

Complement, 1988
The involvement of sialic acids in the microheterogeneity of human complement factor B was investigated. Desialylation kinetics revealed all the charge intermediates from a complex native to a homogeneous form. The relation between this heterogeneity and posttranslational events was explored in cultured hepatoma cells.
Garnier G, Davrinche C, Fontaine M, Charlionet R   +3 more
openaire   +3 more sources

DNA methylation and the origin of complement factor B polymorphism

Human Immunology, 1995
BF is a polymorphic complement component encoded in the MHC. In each of two frequent alleles of BF, BF*FA and BF*FB, the difference in relation to the major allele BF*S has been shown to consist in the nonsynonymous substitution of only one base of the coding sequence.
Georges Hauptmann, Isabelle Jahn, JoséE. Mejía   +2 more
openaire   +3 more sources

Complement component factor B has thrombin-like activity

Biochemical and Biophysical Research Communications, 2021
Serine proteases are fundamental components of biology, including innate immunity, which is systematically orchestrated in an orderly, balanced fashion in the healthy host. Such serine proteases are found in two well-recognized pathways of an innate immune network, coagulation and complement.
Kazue Takahashi, Nirmal K. Banda, V. Michael Holers, Elizabeth M. Van Cott   +3 more
openaire   +3 more sources

Factor B of the Alternative Complement Pathway on Human Lymphocytes

Scandinavian Journal of Immunology, 1976
A factor on human lymphocytes has been identified as factor B of the alternative pathway. Lymphocytes can replace factor B in the fluid phase formation of C3 convertase with cobra venom factor (CVF). This lymphocyte activity is inhibited by specific anti‐human factor B, and it is shown by Burkitt lymphoma cell lines cultured in the absence of any ...
P. J. Lachmann, L. Halbwachs
openaire   +3 more sources

Complement Factor B Polymorphism and the Phenotype of Early Age-related Macular Degeneration

Ophthalmic Genetics, 2014
Purpose: Age-related macular degeneration (AMD) has been associated with a number of polymorphisms in genes in the complement pathway. We examined the potential genotype–phenotype correlation of complement factor B (CFB) (R32Q) polymorphisms in Caucasian
I. Mantel, A. Ambresin, L. Moetteli, I. Droz, R. Roduit, F. Munier, D. Schorderet   +6 more
semanticscholar   +1 more source

Molecular characterization of human complement factor B subtypes

Immunogenetics, 1990
While several laboratories have agreed that there are two subtypes of the BF*F alleles, no information has been available until now at the molecular level. The region of the BF gene corresponding to the Ba fragment [1.7 kilobases (kb)] of the BF*S, BF*FA, and BF*FB alleles has been sequenced after specific amplification using the polymerase chain ...
André Clerc, Christian Davrinche, Michel Abbal   +2 more
openaire   +3 more sources

Complement factor B and the alternative pathway of complement activation in bovine milk

Journal of Dairy Research, 2002
The contribution of the alternative pathway of complement activation to the capacity of normal milk to deposit C3 fragments on bacteria was tested by attempting to block C3 deposition with antibodies to the alternative pathway component factor B (fB).
openaire   +3 more sources