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Comprehensive functional analyses of 110 complement factor B variants provide novel diagnostic and structural insights

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Héctor Martín Merinero   +9 more
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A Novel Case of Complement Factor B Deficiency

Journal of Clinical Immunology, 2020
A. Gauthier   +3 more
semanticscholar   +3 more sources

Antisense therapy targeting complement factor B

Molecular Immunology, 2018
T. R. Grossman   +7 more
semanticscholar   +3 more sources

Complement factor B gene polymorphisms and risk of age-related macular degeneration: A meta-analysis

European Journal of Ophthalmology, 2020
Objective: To investigate the potential correlation between complement factor B polymorphisms and age-related macular degeneration. Methods: We retrieved relevant articles systematically by searching PubMed and Web of Science databases.
Yun Su   +5 more
semanticscholar   +1 more source

Detection of Complement Factor B Autoantibodies by ELISA

2021
Antibodies to autoantigens are implicated in a large number of diseases. Such autoantibodies may cause pathological activation of complement, an ancient humoral recognition and effector system of innate immunity; in addition, complement components or regulators may be target of autoantibodies and cause abnormal complement activation or function ...
Barbara Uzonyi, Mihály Józsi
openaire   +2 more sources

Prognostic potential of the preoperative plasma complement factor B in resected pancreatic cancer: A pilot study

Cancer Biomarkers, 2019
BACKGROUND: For patients with pancreatic cancer, a preoperative assessment of prognosis is crucial to predict cancer recurrence and to prepare a postoperative adjuvant strategy and appropriate patient-counsel.
Sung Hyun Kim   +6 more
semanticscholar   +1 more source

Cloning and sequencing of the porcine complement factor B

Immunogenetics, 1991
A genomic clone, SSBf1, containing the complement factor B (BF), a major histocompatibility class III antigen, has been isolated from a porcine genomic library. Partial sequencing and comparison with a human BF gene has identified seven exons coding for amino acids of Ba and Bb, the two subunits of BF.
Alex Van De Weghe   +4 more
openaire   +3 more sources

Reference Typing Report for Complement Factor B

Experimental and Clinical Immunogenetics, 1998
Factor B (BF) reference typing was carried out on the occasion of the VIIth Complement Genetics Workshop in Mainz, May 1998. Two different sets of samples were analysed by agarose electrophoresis and/or isoelectric focusing at the protein level, and by PCR-RFLP analysis at the DNA level.
Beate Stradmann-Bellinghausen   +4 more
openaire   +2 more sources

Molecular Basis for the Microheterogeneity of Human Complement Factor B

Complement, 1988
The involvement of sialic acids in the microheterogeneity of human complement factor B was investigated. Desialylation kinetics revealed all the charge intermediates from a complex native to a homogeneous form. The relation between this heterogeneity and posttranslational events was explored in cultured hepatoma cells.
Garnier G   +3 more
openaire   +3 more sources

DNA methylation and the origin of complement factor B polymorphism

Human Immunology, 1995
BF is a polymorphic complement component encoded in the MHC. In each of two frequent alleles of BF, BF*FA and BF*FB, the difference in relation to the major allele BF*S has been shown to consist in the nonsynonymous substitution of only one base of the coding sequence.
Georges Hauptmann   +2 more
openaire   +3 more sources

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