Results 191 to 200 of about 1,284,220 (297)

A novel and sensitive functional assay for complement Factor I based on the third proteolytic clip of C3b

, 2018
Peter J. Lachmann, Elizabeth Lay, David J. Seilly   +2 more
openalex   +2 more sources

Modulation of Renal Disease in MRL/lpr Mice Genetically Deficient in the Alternative Complement Pathway Factor B [PDF]

, 2000
Hiroshi Watanabe, Gérard Garnier, Antonella Circolo, Rick A. Wetsel, Phil Ruiz, V. Michael Holers, Susan A. Boackle, Harvey R. Colten, Gary S. Gilkeson   +8 more
openalex   +1 more source

Clinical practice guidelines for the management of atypical haemolytic uraemic syndrome in the United Kingdom [PDF]

, 2010
,, Goodship, Tim H J, Machin, Sam, Taylor, C Mark, Wigmore, Stephen J   +4 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Disease Progression in Age-Related Macular Degeneration Patients Carrying Rare Variants in the Complement Factor H or Complement Factor I Genes. [PDF]

Invest Ophthalmol Vis Sci
Cinque F, de Breuk A, Mhmud H, De Jong S, Vermeulen J, Liefers B, den Hollander AI, Thee E, Colijn JM, Heesterbeek TJ, Klaver CC, Hoyng CB, Lechanteur YTE.   +12 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Complete Complement Factor I (CFI) deficiency: a systematic review of forty-nine patients including three novel cases. [PDF]

BMC Immunol
Rajabi E, Kheirabadi MC, Olyaei NA, Molitor A, Khorshidi MSM, Heidari M, Abbasi A, Rostami P, Mahdavi M, Carapito R, Shahrooei M, Bahram S, Parvaneh N.   +12 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A Case of Atypical Hemolytic Uremic Syndrome With a Complement Factor I Mutation Triggered by a Femoral Neck Fracture. [PDF]

Nephrology (Carlton)
Kano T, Io H, Sasaki Y, Muto M, Muto S, Ogiwara K, Ikeda A, Iwasaki H, Suzuki Y.   +8 more
europepmc   +1 more source