Case Report: Possible C3 nephritic factor-driven complement-mediated severe hemolytic anemia and acute kidney injury in a child with <i>Bordetella parapertussis</i> infection. [PDF]
Thorsen SU +11 more
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Impact of Malaria Infection on the Diagnostic Performance of Adipsin for Preeclampsia in Pregnancy: A Case-Control Study. [PDF]
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A Family with Complement Factor I Deficiency
Scandinavian Journal of Immunology, 1986A family with inherited factor I deficiency is described. The proband was a 19‐year‐old Caucasian female with one episode of meningococcal meningitis and one episode of suspected septicaemia of unknown cause. Two obligate and two probable heterozyotes with factor I levels below the lower limit of the reference range were identified.
J M, Rasmussen +3 more
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Serum complement factor I decreases Staphylococcus aureus phagocytosis
Journal of Laboratory and Clinical Medicine, 2005Complement-mediated opsonization of Staphylococcus aureus is a critical host defense in animal models. Specifically, C3b and CD35 play important roles in effective opsonophagocytosis of S. aureus. We have shown that complement control protein factor I mediates cleavage of the complement opsonin C3b bound to the S. aureus surface.
Kenji M, Cunnion +2 more
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Deficiency of Human Complement Factor I Associated with Lowered Factor H
Clinical Immunology, 2000Deficiencies of factor I and/or factor H result in an increased consumption of C3 and higher susceptibility to recurrent infections. Here we describe a case of human factor I deficiency and lowered factor H levels. C3 concentration was 50% lower than normal, the classical pathway-dependent hemolytic activity was reduced to almost 30% of normal, and ...
G M, Naked +5 more
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Complement factor I deficiency with recurrent aseptic meningitis.
Archives of internal medicine, 1993Patients with deficiency of the complement regulatory protein factor I typically present with systemic pyogenic bacterial infections, including meningitis. We report a novel case with total deficiency of factor I in serum and plasma; the patient experienced nine consecutive episodes of aseptic meningitis within a 2-year period.
A J, Bonnin, H J, Zeitz, A, Gewurz
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A new polymorphic variant of human complement factor I
Human Genetics, 1989Sera from 305 individuals were typed for factor I, and a new variant, tentatively designated FI C, was found. All other samples were FI B except for seven samples from Chinese that were of the FI AB phenotype. This suggests that polymorphism of factor I may be rare in Caucasians.
M, Zhou, B, Larsen
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Glomerulonephritis in a patient with complement factor I deficiency
American Journal of Kidney Diseases, 1999Complement factor I deficiency is known to be associated with recurrent pyogenic infections. The patient described here had recurrent attacks of otitis, sinusitis, and bronchopneumonia since childhood. At the age of 24 years, he had an acute episode of systemic vasculitis with purpura, but no nephritis.
S, Sadallah +4 more
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Abstract Background As a major cause of a myriad of superficial and invasive infections worldwide, Staphylococcus aureus is a master of immune evasion, with the complement system being a primary target. Previously, we have shown that S.
Julia A Sharp +3 more
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In vitro biosynthesis of complement factor I by human endothelial cells
European Journal of Immunology, 1992AbstractWe have studied the secretion of the complement regulatory protein factor I by human umbilical vein endothelial cells (HUVEC). Northern and Western blot analysis and biosynthetic labeling experiments indicate that HUVEC secrete factor I at very low levels in basal conditions and that this secretion is significantly enhanced by interferon‐γ ...
N, Julen +5 more
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