Results 81 to 90 of about 303,951 (335)
A potential tumor suppressor role of PLK2 in glioblastoma
FEBS Open Bio, EarlyView.PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia +5 more
wiley +1 more source
Guiding human gaze with convolutional neural networks [PDF]
arXiv, 2017 The eye fixation patterns of human observers are a fundamental indicator of the aspects of an image to which humans attend. Thus, manipulating fixation patterns to guide human attention is an exciting challenge in digital image processing. Here, we present a new model for manipulating images to change the distribution of human fixations in a controlled
arxiv
Predicting Goal-directed Attention Control Using Inverse-Reinforcement Learning [PDF]
arXiv, 2020 Understanding how goal states control behavior is a question ripe for interrogation by new methods from machine learning. These methods require large and labeled datasets to train models. To annotate a large-scale image dataset with observed search fixations, we collected 16,184 fixations from people searching for either microwaves or clocks in a ...
arxiv
Identification of inhibitors of the Salmonella FraB deglycase, a drug target
FEBS Open Bio, EarlyView.A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law +6 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 1944 Trabalhando com 24 soros provenientes de casos agudos e crônicos cujos diagnósticos foram estabelecidos quer pela pesquisa direta do parasita (casos agudos) quer pelo xenodiagnóstico ou fixação de complemento (casos crônicos) podemos demonstrar em 26 ...
Julio Muniz, Gilberto de Freitas
doaj +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Learning a Saliency Evaluation Metric Using Crowdsourced Perceptual Judgments [PDF]
arXiv, 2018 In the area of human fixation prediction, dozens of computational saliency models are proposed to reveal certain saliency characteristics under different assumptions and definitions. As a result, saliency model benchmarking often requires several evaluation metrics to simultaneously assess saliency models from multiple perspectives.
arxiv
From the classroom to an opinion note: complementary analysis of the genetic structure of the neotropical tree manilkara zapota (L) P. Royen (Sapotaceae) [PDF]
, 2017 Here, we describe a learning strategy that results an excellent choice for a first approach of students to produce scientific knowledge that can be confronted in the scientific field as well as recognize in this knowledge the transferability to the ...
Barrandeguy, Maria Eugenia +2 more
core
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose Volumetric‐modulated arc therapy (VMAT) treatment planning allows a compromise between a sufficient coverage of the planning target volume (PTV) and a simultaneous sparing of organs‐at‐risk (OARs). Particularly in the case of lung tumors, deciding whether it is possible or worth spending more time on further improvements of a treatment
Johann Brand +4 more
wiley +1 more source
Journal of Applied Veterinary Sciences, 2020 The standard serological test such as Rose Bengal Plate Test (RBPT) is routinely used for the diagnosis of brucellosis. This test depends on the agglutination of colored particulate antigen (killed Brucella organisms) by the antibodies present in sera ...
Lamees A. El-Tantawy +3 more
doaj +1 more source