Purified complement C3b triggers phagocytosis and activation of human neutrophils via complement receptor 1 [PDF]
Scientific Reports, 2023 The complement system provides vital immune protection against infectious agents by labeling them with complement fragments that enhance phagocytosis by immune cells.
Elena Boero +12 more
doaj +4 more sources
Mechanism of activation and biased signaling in complement receptor C5aR1. [PDF]
Cell Res, 2023 The complement system plays an important role in the innate immune response to invading pathogens. The complement fragment C5a is one of its important effector components and exerts diverse physiological functions through activation of the C5a receptor 1
Feng Y +12 more
europepmc +2 more sources
The Promiscuous Profile of Complement Receptor 3 in Ligand Binding, Immune Modulation, and Pathophysiology. [PDF]
Front Immunol, 2021 The β2-integrin receptor family has a broad spectrum of physiological functions ranging from leukocyte adhesion, cell migration, activation, and communication to the phagocytic uptake of cells and particles.
Lamers C, Plüss CJ, Ricklin D.
europepmc +2 more sources
Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens. [PDF]
Commun Biol, 2021 Vitamin D deficiency remains a global concern. This ‘sunshine’ vitamin is converted through a multistep process to active 1,25-dihydroxyvitamin D 3 (1,25D), the final step of which can occur in macrophages.
Small AG +9 more
europepmc +2 more sources
Complement Receptor 3 Pathway and NMDA Receptor 2B Subunit Involve Neuropathic Pain Associated with Spinal Cord Injury [PDF]
Journal of Pain Research, 2022 Yong Li,1,* Sheng-Chun Fang,2,* Lan Zhou,1 Xue-Mei Mo,3 Hao-Dong Guo,3 Yan-Bo Deng,3 Hong-Hao Yu,1 Wei-Yi Gong3 1College of Biotechnology, Guilin Medical University, Guilin, Guangxi, 541100, People’s Republic of China; 2Department of ...
Li Y +7 more
doaj +2 more sources
Human Complement Receptor Type 1/CD35 Is an Epstein-Barr Virus Receptor
Cell Reports, 2013 Epstein-Barr virus (EBV) attachment to primary B cells initiates virus entry. Although CD21 is the only known receptor for EBVgp350/220, a recent report documents EBV-infected B cells from a patient genetically deficient in CD21.
Javier G. Ogembo +6 more
doaj +2 more sources
Frontiers in Immunology, 2020 We aimed at establishing a sensitive and robust assay for estimation of systemic complement activation at complement component C3 level in mouse and human plasma samples.
Lene Halkjær +13 more
doaj +2 more sources
Frontiers in Immunology, 2019 Cancer immunotherapy has made remarkable clinical advances in recent years. Antibodies targeting the immune checkpoint receptors PD-1 and CTLA-4 and adoptive cell therapy (ACT) based on ex vivo expanded peripheral CTLs, tumor infiltrating lymphocytes ...
Yu Wang, Hui Zhang, You-Wen He
doaj +2 more sources
Nature Communications, 2018 Complement, while serving to remove pathogens in the circulation, is also important for synergizing with inflammasomes to modulate CD4 T cell activation.
Giuseppina Arbore +21 more
doaj +2 more sources
Mesenchymal stromal cells engage complement and complement receptor bearing innate effector cells to modulate immune responses. [PDF]
PLoS ONE, 2011 Infusion of human third-party mesenchymal stromal cells (MSCs) appears to be a promising therapy for acute graft-versus-host disease (aGvHD). To date, little is known about how MSCs interact with the body's innate immune system after clinical infusion ...
Guido Moll +12 more
doaj +2 more sources