Results 1 to 10 of about 5,517 (100)

Aspects of the Complement System in New Era of Xenotransplantation

Frontiers in Immunology, 2022
After producing triple (Gal, H-D and Sda)-KO pigs, hyperacute rejection appeared to no longer be a problem. However, the origin of xeno-rejection continues to be a controversial topic, including small amounts of antibodies and subsequent activation of ...
Shuji Miyagawa, Shuji Miyagawa, Shuji Miyagawa, Akira Maeda, Chiyoshi Toyama, Shuhei Kogata, Chizu Okamatsu, Riho Yamamoto, Kazunori Masahata, Masafumi Kamiyama, Hiroshi Eguchi, Masahito Watanabe, Hiroshi Nagashima, Masahito Ikawa, Katsuyoshi Matsunami, Hiroomi Okuyama   +15 more
doaj   +1 more source

A Novel Image Analysis Approach Reveals a Role for Complement Receptors 1 and 2 in Follicular Dendritic Cell Organization in Germinal Centers

Frontiers in Immunology, 2021
Follicular dendritic cells (FDCs) are rare and enigmatic cells that mainly reside in germinal centers (GCs). They are capable of capturing immune complexes, via their Fc (FcRs) and complement receptors (CRs) and storing them for long periods in non ...
Jessica C. Anania, Annika Westin, Jeremy Adler, Birgitta Heyman   +3 more
doaj   +1 more source

Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis

Frontiers in Cellular Neuroscience, 2023
BackgroundThe extent of cortical pathology is an important determinant of multiple sclerosis (MS) severity. Cortical demyelination and neurodegeneration are related to inflammation of the overlying leptomeninges, a more inflammatory CSF milieu and with ...
Rhian Evans, Lewis M. Watkins, Kristen Hawkins, Gabriella Santiago, Constantinos Demetriou, Michelle Naughton, Marie Dittmer, Mark I. Rees, Denise Fitzgerald, B. Paul Morgan, James W. Neal, Owain W. Howell   +11 more
doaj   +1 more source

Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer

Journal for ImmunoTherapy of Cancer, 2021
Background Resistance to therapy is a major problem in treating head and neck squamous cell carcinomas (HNSCC). Complement system inhibition has been shown to reduce tumor growth, metastasis, and therapeutic resistance in other tumor models, but has yet ...
Emily K Kleczko, Raphael A Nemenoff, Michael William Knitz   +2 more
doaj   +1 more source

Role of Mac-1 integrin in generation of extracellular vesicles with antibacterial capacity from neutrophilic granulocytes

Journal of Extracellular Vesicles, 2020
Production of extracellular vesicles (EVs) involved in intercellular communication is a common capacity of most cell types. Upon encountering opsonized microorganisms, neutrophilic granulocytes release EVs that compromise bacterial growth. We carried out
Ákos M. Lőrincz, Balázs Bartos, Dávid Szombath, Viktória Szeifert, Csaba I. Timár, Lilla Turiák, László Drahos, Ágnes Kittel, Dániel S. Veres, Ferenc Kolonics, Attila Mócsai, Erzsébet Ligeti   +11 more
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Purified complement C3b triggers phagocytosis and activation of human neutrophils via complement receptor 1

Scientific Reports, 2023
The complement system provides vital immune protection against infectious agents by labeling them with complement fragments that enhance phagocytosis by immune cells.
Elena Boero, Ronald D. Gorham, Emmet A. Francis, Jonathan Brand, Lay Heng Teng, Dennis J. Doorduijn, Maartje Ruyken, Remy M. Muts, Christian Lehmann, Admar Verschoor, Kok P. M. van Kessel, Volkmar Heinrich, Suzan H. M. Rooijakkers   +12 more
doaj   +1 more source

Complement Receptor 3-Mediated Inhibition of Inflammasome Priming by Ras GTPase-Activating Protein During Francisella tularensis Phagocytosis by Human Mononuclear Phagocytes

Frontiers in Immunology, 2018
Francisella tularensis is a remarkably infectious facultative intracellular bacterium of macrophages that causes tularemia. Early evasion of host immune responses contributes to the success of F. tularensis as a pathogen. F.
Ky V. Hoang, Murugesan V. S. Rajaram, Heather Marie Curry, Mikhail A. Gavrilin, Mark D. Wewers, Larry S. Schlesinger, Larry S. Schlesinger   +6 more
doaj   +1 more source

Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum. [PDF]

PLoS Pathogens, 2010
Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of erythrocyte invasion are incompletely understood.
Carmenza Spadafora, Gordon A Awandare, Karen M Kopydlowski, Jozsef Czege, J Kathleen Moch, Robert W Finberg, George C Tsokos, José A Stoute   +7 more
doaj   +1 more source

Complement Inhibitor Therapy for Myasthenia Gravis

Frontiers in Immunology, 2020
Complement activation as a driver of pathology in myasthenia gravis (MG) has been appreciated for decades. The terminal complement component [membrane attack complex (MAC)] is found at the neuromuscular junctions of patients with MG.
Khaled Albazli, Henry J. Kaminski, James F. Howard   +2 more
doaj   +1 more source

Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis. [PDF]

PLoS Neglected Tropical Diseases, 2010
The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B.
Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J Cutler, Markus M Simon, Reinhard Wallich   +5 more
doaj   +1 more source