Results 11 to 20 of about 5,517 (100)

The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor

Nature Communications, 2022
Complement activation on foreign cell surfaces leads to the generation of complement opsonins, which activate complement receptor type 3 (CR3) and pathogen clearance by macrophages.
Francisco J. Fernández, Jorge Santos-López, Rubén Martínez-Barricarte, Javier Querol-García, Héctor Martín-Merinero, Sergio Navas-Yuste, Martin Savko, William E. Shepard, Santiago Rodríguez de Córdoba, M. Cristina Vega   +9 more
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Human Complement Receptor Type 1/CD35 Is an Epstein-Barr Virus Receptor

Cell Reports, 2013
Epstein-Barr virus (EBV) attachment to primary B cells initiates virus entry. Although CD21 is the only known receptor for EBVgp350/220, a recent report documents EBV-infected B cells from a patient genetically deficient in CD21.
Javier G. Ogembo, Lakshmi Kannan, Ionita Ghiran, Anne Nicholson-Weller, Robert W. Finberg, George C. Tsokos, Joyce D. Fingeroth   +6 more
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Complement activation contributes to perioperative neurocognitive disorders in mice

Journal of Neuroinflammation, 2018
Background The complement system plays an important role in many neurological disorders. Complement modulation, including C3/C3a receptor signaling, shows promising therapeutic effects on cognition and neurodegeneration.
Chao Xiong, Jinhu Liu, Dandan Lin, Juxia Zhang, Niccolò Terrando, Anshi Wu   +5 more
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Complement Receptor 2 Based Immunoassay Measuring Activation of the Complement System at C3-Level in Plasma Samples From Mice and Humans

Frontiers in Immunology, 2020
We aimed at establishing a sensitive and robust assay for estimation of systemic complement activation at complement component C3 level in mouse and human plasma samples.
Lene Halkjær, Lene Halkjær, Lene Halkjær, Anne Troldborg, Anne Troldborg, Anne Troldborg, Henrik Pedersen, Lisbeth Jensen, Annette Gudmann Hansen, Troels Krarup Hansen, Mette Bjerre, Jakob Appel Østergaard, Jakob Appel Østergaard, Steffen Thiel   +13 more
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Role of complement in myasthenia gravis

Frontiers in Neurology, 2023
Myasthenia gravis is a prototypic neuroimmune disorder with autoantibodies targeting the acetylcholine receptor complex at the neuromuscular junction.
Pyae Phyo San, Saiju Jacob, Saiju Jacob
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Cytokine and Complement Response in the Glaucomatous βB1-CTGF Mouse Model

Frontiers in Cellular Neuroscience, 2021
Glaucoma is a complex neurodegenerative disease leading to a loss of retinal ganglion cells (RGCs) and optic nerve axons. An activation of the complement system seems to contribute to cell loss in this disease.
Sabrina Reinehr, Johanna D. Doerner, Ana M. Mueller-Buehl, Dennis Koch, Rudolf Fuchshofer, H. Burkhard Dick, Stephanie C. Joachim   +6 more
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Vasoregulatory Autoantibodies and Clinical Outcome After Ischemic Stroke—PROSCIS‐B

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Vasoregulatory autoantibodies including autoantibodies targeting G‐protein–coupled receptors might play a functional role in vascular diseases.
Thomas G. Liman, Bob Siegerink, Sophie Piper, Rusan Catar, Guido Moll, Gabriela Riemekasten, Harald Heidecke, Peter U. Heuschmann, Mitchell S. V. Elkind, Duska Dragun, Matthias Endres   +10 more
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A novel approach to inhibit HIV-1 infection and enhance lysis of HIV by a targeted activator of complement

Virology Journal, 2009
Background The complement system is one of the most potent weapons of innate immunity. It is not only a mechanism for direct protection against invading pathogens but it also interacts with the adaptive immunity to optimize the pathogen-specific humoral ...
Huang Liuyu, Sun Yansong, Wang Yong, Liu Huihui, Wen Cuirong, Jia Leili, Zhang Chuanfu, Xu Yuanyong, Zhou Yusen, Song Hongbin   +9 more
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Complement Receptor 3 Pathway and NMDA Receptor 2B Subunit Involve Neuropathic Pain Associated with Spinal Cord Injury

Journal of Pain Research, 2022
Yong Li,1,* Sheng-Chun Fang,2,* Lan Zhou,1 Xue-Mei Mo,3 Hao-Dong Guo,3 Yan-Bo Deng,3 Hong-Hao Yu,1 Wei-Yi Gong3 1College of Biotechnology, Guilin Medical University, Guilin, Guangxi, 541100, People’s Republic of China; 2Department of ...
Li Y, Fang SC, Zhou L, Mo XM, Guo HD, Deng YB, Yu HH, Gong WY   +7 more
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Francisella tularensis Confronts the Complement System

Frontiers in Cellular and Infection Microbiology, 2017
Francisella tularensis has developed a number of effective evasion strategies to counteract host immune defenses, not the least of which is its ability to interact with the complement system to its own advantage.
Susan R. Brock, Michael J. Parmely
doaj   +1 more source