Results 21 to 30 of about 3,236,190 (349)

Complement Receptor 3-Mediated Inhibition of Inflammasome Priming by Ras GTPase-Activating Protein During Francisella tularensis Phagocytosis by Human Mononuclear Phagocytes

Frontiers in Immunology, 2018
Francisella tularensis is a remarkably infectious facultative intracellular bacterium of macrophages that causes tularemia. Early evasion of host immune responses contributes to the success of F. tularensis as a pathogen. F.
Ky V. Hoang, Murugesan V. S. Rajaram, Heather Marie Curry, Mikhail A. Gavrilin, Mark D. Wewers, Larry S. Schlesinger, Larry S. Schlesinger   +6 more
doaj   +1 more source

Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum. [PDF]

PLoS Pathogens, 2010
Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of erythrocyte invasion are incompletely understood.
Carmenza Spadafora, Gordon A Awandare, Karen M Kopydlowski, Jozsef Czege, J Kathleen Moch, Robert W Finberg, George C Tsokos, José A Stoute   +7 more
doaj   +1 more source

Complement Inhibitor Therapy for Myasthenia Gravis

Frontiers in Immunology, 2020
Complement activation as a driver of pathology in myasthenia gravis (MG) has been appreciated for decades. The terminal complement component [membrane attack complex (MAC)] is found at the neuromuscular junctions of patients with MG.
Khaled Albazli, Henry J. Kaminski, James F. Howard   +2 more
doaj   +1 more source

Coupling of β2 integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis

Nature Cell Biology, 2019
αMβ2 integrin (complement receptor 3) is a major receptor for phagocytosis in macrophages. In other contexts, integrins’ activities and functions are mechanically linked to actin dynamics through focal adhesions.
Valentin Jaumouillé, A. Cartagena-Rivera, Clare M. Waterman   +2 more
semanticscholar   +1 more source

Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis. [PDF]

PLoS Neglected Tropical Diseases, 2010
The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B.
Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J Cutler, Markus M Simon, Reinhard Wallich   +5 more
doaj   +1 more source

CR2 Complement Receptor

Journal of Investigative Dermatology, 1990
CR2, a membrane glycoprotein, is one of a number of cell-surface proteins which bind activation and processing fragments of the complement system. CR2, which is found on normal B lymphocytes, follicular dendritic cells in lymphoid organs, and epithelial cells, interacts preferentially with C3dg, the terminal activation/processing fragment of the third ...
Cooper, Neil R, Bradt, Bonnie M, Rhim, Johng S, Nemerow, Glen R   +3 more
openaire   +2 more sources

The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity

Journal of Immunology, 2019
Complement activation generates the core effector protein C5a, a potent immune molecule that is linked to multiple inflammatory diseases. Two C5a receptors, C5aR1 (C5aR, CD88) and C5aR2 (C5L2, GPR77), mediate the biological activities of C5a.
Xaria X. Li, John D. Lee, C. Kemper, T. Woodruff   +3 more
semanticscholar   +1 more source

Blockade of the kallikrein-kinin system reduces endothelial complement activation in vascular inflammationResearch in context

EBioMedicine, 2019
Background: The complement and kallikrein-kinin systems (KKS) are activated during vascular inflammation. The aim of this study was to investigate if blockade of the KKS can affect complement activation on the endothelium during inflammation.
Ingrid Lopatko Fagerström, Anne-lie Ståhl, Maria Mossberg, Ramesh Tati, Ann-Charlotte Kristoffersson, Robin Kahn, Jean-Loup Bascands, Julie Klein, Joost P. Schanstra, Mårten Segelmark, Diana Karpman   +10 more
doaj   +1 more source

The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor

Nature Communications, 2022
Complement activation on foreign cell surfaces leads to the generation of complement opsonins, which activate complement receptor type 3 (CR3) and pathogen clearance by macrophages.
Francisco J. Fernández, Jorge Santos-López, Rubén Martínez-Barricarte, Javier Querol-García, Héctor Martín-Merinero, Sergio Navas-Yuste, Martin Savko, William E. Shepard, Santiago Rodríguez de Córdoba, M. Cristina Vega   +9 more
doaj   +1 more source

Complement activation contributes to perioperative neurocognitive disorders in mice

Journal of Neuroinflammation, 2018
Background The complement system plays an important role in many neurological disorders. Complement modulation, including C3/C3a receptor signaling, shows promising therapeutic effects on cognition and neurodegeneration.
Chao Xiong, Jinhu Liu, Dandan Lin, Juxia Zhang, Niccolò Terrando, Anshi Wu   +5 more
doaj   +1 more source