Results 31 to 40 of about 3,236,190 (349)

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

Journal of Experimental Medicine, 2017
Recent genetic evidence supports a link between microglia and the complement system in Alzheimer’s disease (AD). In this study, we uncovered a novel role for the microglial complement receptor 3 (CR3) in the regulation of soluble &bgr;-amyloid (A&bgr ...
Eva Czirr, Nicholas A. Castello, Kira I. Mosher, Joseph M. Castellano, Izumi V. Hinkson, Kurt M. Lucin, B. Baeza-Raja, J. Ryu, Lulin Li, S. N. Farina, Nadia P. Belichenko, F. Longo, K. Akassoglou, Markus Britschgi, J. Cirrito, T. Wyss-Coray   +15 more
semanticscholar   +1 more source

Complement C2 Receptor Inhibitor Trispanning: A Novel Human Complement Inhibitory Receptor [PDF]

The Journal of Immunology, 2005
AbstractThe complement system presents a powerful defense against infection and is tightly regulated to prevent damage to self by functionally equivalent soluble and membrane regulators. We describe complement C2 receptor inhibitor trispanning (CRIT), a novel human complement regulatory receptor, expressed on hemopoietic cells and a wide range of ...
Jameel M, Inal, Kwok-Min, Hui, Sylvie, Miot, Sigrun, Lange, Marcel Ivan, Ramirez, Brigitte, Schneider, Gerhard, Krueger, Jürg-A, Schifferli   +7 more
openaire   +2 more sources

Role of complement in myasthenia gravis

Frontiers in Neurology, 2023
Myasthenia gravis is a prototypic neuroimmune disorder with autoantibodies targeting the acetylcholine receptor complex at the neuromuscular junction.
Pyae Phyo San, Saiju Jacob, Saiju Jacob
doaj   +1 more source

Vasoregulatory Autoantibodies and Clinical Outcome After Ischemic Stroke—PROSCIS‐B

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Vasoregulatory autoantibodies including autoantibodies targeting G‐protein–coupled receptors might play a functional role in vascular diseases.
Thomas G. Liman, Bob Siegerink, Sophie Piper, Rusan Catar, Guido Moll, Gabriela Riemekasten, Harald Heidecke, Peter U. Heuschmann, Mitchell S. V. Elkind, Duska Dragun, Matthias Endres   +10 more
doaj   +1 more source

Complement receptor immunoglobulin: a control point in infection and immunity, inflammation and cancer.

Swiss medical weekly, 2016
The B7 family-related protein, V-set and Ig domain (VSIG4) / Z39Ig / complement receptor immunoglobulin (CRIg), is a new player in the regulation of immunity to infection and inflammation.
A. Small, M. Al-Baghdadi, Alex Quach, C. Hii, A. Ferrante   +4 more
semanticscholar   +1 more source

Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway

Cell Reports, 2023
Summary: Complement activation is thought to underline the pathologic progression of obesity-related metabolic disorders; however, its role in adaptive thermogenesis has scarcely been explored.
Ling-Ran Kong, Xiao-Hui Chen, Qing Sun, Kai-Yuan Zhang, Lian Xu, Liliqiang Ding, Yan-Ping Zhou, Ze-Bei Zhang, Jing-Rong Lin, Ping-Jin Gao   +9 more
doaj   +1 more source

Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

Frontiers in Immunology, 2017
Glycosylation of the immunoglobulin G (IgG)-Fc tail is required for binding to Fc-gamma receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is detected in human sera.
G. Dekkers, Louise W Treffers, R. Plomp, A. Bentlage, M. de Boer, C. Koeleman, Suzanne N. Lissenberg-Thunnissen, R. Visser, M. Brouwer, J. Y. Mok, H. Matlung, T. K. van den Berg, Wim J E van Esch, T. Kuijpers, D. Wouters, T. Rispens, M. Wuhrer, G. Vidarsson   +17 more
semanticscholar   +1 more source

A novel approach to inhibit HIV-1 infection and enhance lysis of HIV by a targeted activator of complement

Virology Journal, 2009
Background The complement system is one of the most potent weapons of innate immunity. It is not only a mechanism for direct protection against invading pathogens but it also interacts with the adaptive immunity to optimize the pathogen-specific humoral ...
Huang Liuyu, Sun Yansong, Wang Yong, Liu Huihui, Wen Cuirong, Jia Leili, Zhang Chuanfu, Xu Yuanyong, Zhou Yusen, Song Hongbin   +9 more
doaj   +1 more source

Cytokine and Complement Response in the Glaucomatous βB1-CTGF Mouse Model

Frontiers in Cellular Neuroscience, 2021
Glaucoma is a complex neurodegenerative disease leading to a loss of retinal ganglion cells (RGCs) and optic nerve axons. An activation of the complement system seems to contribute to cell loss in this disease.
Sabrina Reinehr, Johanna D. Doerner, Ana M. Mueller-Buehl, Dennis Koch, Rudolf Fuchshofer, H. Burkhard Dick, Stephanie C. Joachim   +6 more
doaj   +1 more source

Francisella tularensis Confronts the Complement System

Frontiers in Cellular and Infection Microbiology, 2017
Francisella tularensis has developed a number of effective evasion strategies to counteract host immune defenses, not the least of which is its ability to interact with the complement system to its own advantage.
Susan R. Brock, Michael J. Parmely
doaj   +1 more source