Results 41 to 50 of about 3,236,190 (349)
C3‐dependent effector functions of complement
Immunological Reviews, 2022 C3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding receptors. We will introduce the C3 forms (native C3, C3 [H2O], and intracellular C3), the C3 fragments
A. Zarantonello +3 more
semanticscholar +1 more source
Journal of Translational Medicine, 2020 Background Typically minor ABO incompatible platelet products are transfused without any incident, yet serious hemolytic transfusion reactions occur. To mitigate these events, ABO ‘low titer’ products are used for minor ABO incompatible transfusions.
Priyanka Pandey +4 more
doaj +1 more source
Complement inhibition promotes endogenous neurogenesis and sustained anti-inflammatory neuroprotection following reperfused stroke. [PDF]
PLoS ONE, 2012 The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent
Andrew F Ducruet +11 more
doaj +1 more source
Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3
eLife, 2015 Integrins are heterodimeric cell surface adhesion and signaling receptors that are essential for metazoan existence. Some integrins contain an I-domain that is a major ligand binding site.
Radim Osicka +5 more
semanticscholar +1 more source
New insights for C5a and C5a receptors in sepsis
Frontiers in Immunology, 2012 The complement system plays a central role in inflammation and immunity. Among the complement activation products, C5a is one of the most potent inflammatory peptides with a broad spectrum of functions.
Hongwei eGao, Chunguang eYan
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura +5 more
wiley +1 more source
Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant
Frontiers in Immunology, 2019 Co-ligation of the B cell antigen receptor with complement receptor 2 on B-cells via a C3d-opsonised antigen complex significantly lowers the threshold required for B cell activation.
Yi Yang +13 more
doaj +1 more source
The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice. [PDF]
PLoS ONE, 2013 Inflammatory bowel diseases are a critical public health issue, and as treatment options remain limited, there is a need to unravel the underlying pathomechanisms in order to identify new therapeutic targets.
Elisabeth Wende +6 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events.
Alexandros Rahn +4 more
wiley +1 more source
Haematologica, 2014 Complement blockade by eculizumab is clinically effective in hemolytic paroxysmal nocturnal hemoglobinuria. However, the response is variable and some patients remain dependent on red blood cell transfusions.
Tommaso Rondelli +14 more
semanticscholar +1 more source