Results 41 to 50 of about 5,517 (100)

Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation

Respiratory Research
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) pandemic has challenged the current understanding of the complement cascade mechanisms of host immune responses during infection-induced ...
Pooja Shivshankar, Stacey L. Mueller-Ortiz, Aleksey Y. Domozhirov, Weizhen Bi, Scott D. Collum, Marie-Francoise Doursout, Manish Patel, Isabella N. LeFebvre, Bindu Akkanti, Simon Yau, Howard J. Huang, Rahat Hussain, Harry Karmouty-Quintana   +12 more
doaj   +1 more source

Complement Receptor Type 1 Suppresses Human B Cell Functions in SLE Patients

Journal of Immunology Research, 2016
Complement receptors (CRs) play an integral role in innate immunity and also function to initiate and shape the adaptive immune response. Our earlier results showed that complement receptor type 1 (CR1, CD35) is a potent inhibitor of the B cell receptor-
Mariann Kremlitzka, Bernadett Mácsik-Valent, Anna Polgár, Emese Kiss, Gyula Poór, Anna Erdei   +5 more
doaj   +1 more source

Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production

Frontiers in Immunology, 2019
Complement factor H (CFH) has a pivotal role in regulating alternative complement activation through its ability to inhibit the cleavage of the central complement component C3, which links innate and humoral immunity.
Máté G. Kiss, Máté G. Kiss, Mária Ozsvár-Kozma, Mária Ozsvár-Kozma, Florentina Porsch, Florentina Porsch, Laura Göderle, Laura Göderle, Nikolina Papac-Miličević, Nikolina Papac-Miličević, Barbara Bartolini-Gritti, Barbara Bartolini-Gritti, Dimitrios Tsiantoulas, Dimitrios Tsiantoulas, Matthew C. Pickering, Christoph J. Binder, Christoph J. Binder   +16 more
doaj   +1 more source

A Review: Does Complement or the Contact System Have a Role in Protection or Pathogenesis of COVID-19?

Pulmonary Therapy, 2020
Introduction COVID-19 presentation may include a profound increase in cytokines and associated pneumonia, rapidly progressing to acute respiratory distress syndrome (ARDS). This so-called cytokine storm often leads to refractory edema, respiratory arrest,
Natella Maglakelidze, Kristen M. Manto, Timothy J. Craig   +2 more
doaj   +1 more source

Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis

Journal of Inflammation, 2012
Background Myasthenia gravis (MG) and animal model of experimental autoimmune myasthenia gravis (EAMG) is the most common autoimmune disorder of neuromuscular transmission. The disease is caused by the breakdown of the acetylcholine receptor (AChR) which
Soltys Jindrich, Wu Xiaobo
doaj   +1 more source

Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis.

PLoS Pathogens, 2008
Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be involved in recognition and phagocytosis of this fungus ...
Sigrid E M Heinsbroek, Philip R Taylor, Fernando O Martinez, Luisa Martinez-Pomares, Gordon D Brown, Siamon Gordon   +5 more
doaj   +1 more source

Pharmacological Stimulation of Phagocytosis Enhances Amyloid Plaque Clearance; Evidence from a Transgenic Mouse Model of ATTR Neuropathy

Frontiers in Molecular Neuroscience, 2017
Hereditary ATTR V30M amyloidosis is a lethal autosomal dominant sensorimotor and autonomic neuropathy caused by deposition of aberrant transthyretin (TTR).
Eleni Fella, Eleni Fella, Kleitos Sokratous, Kleitos Sokratous, Revekka Papacharalambous, Kyriacos Kyriacou, Kyriacos Kyriacou, Joy Phillips, Sam Sanderson, Elena Panayiotou, Theodoros Kyriakides, Theodoros Kyriakides   +11 more
doaj   +1 more source

2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages II. Dissociation of the inhibitory effects of 2-deoxyglucose on phagocytosis and ATP generation. [PDF]

, 1976
Josef Michl, D J Ohlbaum, Samuel C. Silverstein   +2 more
openalex   +1 more source

Complement and Fc Receptors on Cord Blood and Adult Neutrophils [PDF]

, 1977
Susan Pross, James A. Hallock, Rufus Armstrong, C. W. Fishel   +3 more
openalex   +1 more source

Increased Proportion of Complement-Receptor Lymphocytes in the Peripheral Blood of Patients With Chronic Lymphocytic Leukemia [PDF]

, 1972
Seth H. Pincus, Celso Bianco, Victor Nussenzweig   +2 more
openalex   +1 more source