Results 91 to 100 of about 373,594 (283)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Quark-lepton symmetry and complementarity
, 2005 We argue that the difference between the observed approximate quark-lepton complementarity and the theoretical prediction based on realistic quark-lepton symmetry within the seesaw mechanism may be adjusted by means of a triplet contribution in the ...
D. FALCONE, Gell-Mann M., Glashow S. L.
core +1 more source
Universal complementarity between coherence and intrinsic concurrence for two-qubit states
New Journal of Physics, 2019 Entanglement and coherence are two essential quantum resources for quantum information processing. A natural question arises of whether there is a direct link between them.
Xiao-Gang Fan +6 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Unitarity and fuzzball complementarity: "Alice fuzzes but may not even know it!"
, 2013 We investigate the recent black hole firewall argument. For a black hole in a typical state we argue that unitarity requires every quantum of radiation leaving the black hole to carry information about the initial state.
Avery, Steven G. +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Finite automata models of quantized systems: conceptual status and outlook [PDF]
, 2002 Since Edward Moore, finite automata theory has been inspired by physics, in particular by quantum complementarity. We review automaton complementarity, reversible automata and the connections to generalized urn models.
Svozil, Karl
core +4 more sources
Tensor Complementarity Problem and Semi-positive Tensors
, 2015 The tensor complementarity problem $(\q, \mathcal{A})$ is to $$\mbox{ find } \x \in \mathbb{R}^n\mbox{ such that }\x \geq \0, \q + \mathcal{A}\x^{m-1} \geq \0, \mbox{ and }\x^\top (\q + \mathcal{A}\x^{m-1}) = 0.$$ We prove that a real tensor $\mathcal ...
Qi, Liqun, Song, Yisheng
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source