Results 71 to 80 of about 286,109 (296)

Volcanic caves: priorities for conserving the Azorean endemic troglobiont species

International Journal of Speleology, 2012
Azorean lava-tubes and volcanic pits adequately sampled for arthropod fauna were evaluated for species diversity and rarity. An iterative partial multiple regression analysis was performed to produce a multi-criteria index (Importance Value for Cave ...
Borges Paulo A.V., Cardoso Pedro, Amorim Isabel R., Pereira Fernando, Constância João P., Nunes João C., Barcelos Paulo, Costa Paulino, Gabriel Rosalina, Dapkevicius Maria de Lurdes   +9 more
doaj  

Customer complementarity in the digital space: Exploring Amazon’s business model diversification

, 2020
In spite of the striking evidence that many firms run multiple business models, scholars and practitioners still lack a comprehensive understanding about business model portfolio dynamics, particularly when this happens in the digital space.
P. Aversa, Stefan Haefliger, Francesca Hueller, D. Reza   +3 more
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

La Relación entre las Estrategias de Innovación: Coexistencia o Complementariedad

Journal of Technology Management & Innovation, 2009
This paper explores the relationships between internal R&D and external knowledge acquisition as business innovation strategies. Drawing on absorptive capacity framework (Cohen and Levinthal, 1990), we distinguish and empirically evaluate two possible ...
Jaider Manuel Vega Jurado, Antonio Gutiérrez-Gracia, Ignacio Fernández-de-Lucio   +2 more
doaj   +1 more source

How Strategic Behavior of Natural Gas Exporters Can Affect the Sectors of Electricity, Heating, and Emission Trading during the European Energy Transition

Energies, 2020
The European demand for natural gas imports may change through the energy transition, which may affect natural gas exporters’ strategic behavior and consequently the natural gas prices.
Sina Heidari
doaj   +1 more source

Modulus-based matrix splitting methods for horizontal linear complementarity problems

Numerical Algorithms, 2019
In this paper, we extend modulus-based matrix splitting iteration methods to horizontal linear complementarity problems. We consider both standard and accelerated methods and analyze their convergence. In this context, we also generalize existing results
F. Mezzadri, E. Galligani
semanticscholar   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

broadinstitute/lincs-profiling-complementarity: Paper submission DOI

, 2021
The same repository state as https://github.com/broadinstitute/lincs-profiling-complementarity/releases/tag/v1 but added to mint Zenodo ...
Gregory Way, Adeniyi Adeboye, Shantanu Singh   +2 more
core   +1 more source