Results 71 to 80 of about 369,892 (263)
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
RodriguésiaDuas teorias em ecologia explicam a distribuição de espécies em florestas tropicais: a Teoria Neutra e a Teoria do Nicho. Na primeira a distribuição de espécies está relacionada a processos como dispersão, enquanto a segunda prediz que é devido às ...
Darley C. Leal Matos +2 more
doaj +1 more source
Performance Philosophy, 2017 In this article, the conceptual history of space in physics will be presented in the context of transcendent and immanent concepts. In short, transcendent concepts postulate space as an ambient super-structure to organize material objects, while in ...
Tanja Traxler
doaj +1 more source
Bohr's way to defining complementarity
, 2013 We go through Bohr's talk about complementary features of quantum theory at the Volta Conference in September 1927, by collating a manuscript that Bohr wrote in Como with the unpublished stenographic report of his talk.
De Gregorio, Alberto
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Uncertainty reconciles complementarity with joint measurability
, 2002 The fundamental principles of complementarity and uncertainty are shown to be related to the possibility of joint unsharp measurements of pairs of noncommuting quantum observables. A new joint measurement scheme for complementary observables is proposed.
A. Luis +11 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Justiciability, Complementarity and Immunity: Reflections on the crime of aggression
Utrecht Law Review, 2017 Some 70 years after the first and, so far the only, criminal prosecutions pertaining to the ‘supreme international crime’ took place, the activation of the – long dormant – jurisdiction of the International Criminal Court (ICC) over the crime of ...
Tom Ruys
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source