Results 241 to 250 of about 25,476 (265)
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Immunoglobulin functional motions and their effects on the complementarity determining regions
Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology, 2010Motions of the IgG structure are evaluated using normal mode analysis and a new time dependent form of the elastic network model, to detect hinges, the dominance of low frequency modes, and the most important internal motions. We also evaluate the protein crystal and its packing effects on the experimental temperature factors and disorder prediction ...
Michael T. Zimmermann +4 more
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Crystal structure of a T cell receptor Vα11 (AV11S5) domain: new canonical forms for the first and second complementarity determining regions [PDF]
Journal of Molecular Biology, 2001 We describe the X-ray crystallographic structure of a murine T cell receptor (TCR) Vα domain ("Vα85.33"; AV11S5-AJ17) to 1.85 Å resolution. The Vα85.33 domain is derived from a TCR that recognizes a type II collagen peptide associated with the murine ...
Mischa Machius +2 more
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HIC resolution of an IgG1 with an oxidized Trp in a complementarity determining region
Journal of Chromatography B, 2011Susceptibility of tryptophan (Trp) in a complementarity-determining region (CDR) to oxidation is a significant issue for recombinant monoclonal antibody (mAb) therapeutics due to the clinical efficacy and stability concerns. Here we present a case study using hydrophobic interaction chromatography (HIC) to separate an oxidized Trp containing population
Daniel, Boyd +2 more
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Design and Synthesis of a Mimetic from an Antibody Complementarity-Determining Region
Science, 1991A technique for producing non-peptide compounds (mimetics) of designed specificities was developed that permitted the synthesis of a conformationally restricted molecule that mimicked the binding and functional properties of monoclonal antibody (MAb) 87.92.6, which recognizes the reovirus type 3 cellular receptor. Binding of either MAb 87.92.6, peptide
H U, Saragovi +5 more
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Molecular Phylogenetics and Evolution, 1992
To determine the relative importance of gene conversion followed by natural selection and of natural selection for point mutation in generating variability in immunoglobulins, the numbers of synonymous and nonsynonymous substitutions in immunoglobulin sequences of various subgroups were estimated for complementarity-determining regions (CDRs) and for ...
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To determine the relative importance of gene conversion followed by natural selection and of natural selection for point mutation in generating variability in immunoglobulins, the numbers of synonymous and nonsynonymous substitutions in immunoglobulin sequences of various subgroups were estimated for complementarity-determining regions (CDRs) and for ...
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Computational Biology and Chemistry, 2016
For the rational design of antibody, it is important to clarify the characteristics of the interaction between antigen and antibody. In this study, we evaluated a contribution of the respective complementarity determining region (CDR) loops on the antibody recognition of antigen by performing molecular dynamics simulations for 20 kinds of antigen ...
Tomonori Osajima, Tyuji Hoshino
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For the rational design of antibody, it is important to clarify the characteristics of the interaction between antigen and antibody. In this study, we evaluated a contribution of the respective complementarity determining region (CDR) loops on the antibody recognition of antigen by performing molecular dynamics simulations for 20 kinds of antigen ...
Tomonori Osajima, Tyuji Hoshino
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Peptide Aptamer of Complementarity-determining Region to Detect Avian Influenza Virus
Journal of Biomedical Nanotechnology, 2019Despite significant progress in the development of diagnostic methods for influenza, avian influenza (AI) infection continues to represent a substantial threat to human health. Among the subtypes of AI, H5 influenza is highly infectious to animals and humans; however, there are no reliable H5 subtype-specific diagnostic systems owing to a scarcity of ...
Anh Thi Viet, Nguyen +7 more
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Nature Biotechnology, 2007
Here we show that fusion of two complementarity-determining regions (CDRs), VHCDR1 and VLCDR3, through a cognate framework region (VHFR2) yields mimetics that retain the antigen recognition of their parent molecules, but have a superior capacity to penetrate tumors.
Xiao-Qing, Qiu +4 more
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Here we show that fusion of two complementarity-determining regions (CDRs), VHCDR1 and VLCDR3, through a cognate framework region (VHFR2) yields mimetics that retain the antigen recognition of their parent molecules, but have a superior capacity to penetrate tumors.
Xiao-Qing, Qiu +4 more
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Complementarity-determining region (CDR) implantation: a theme of recombination.
Immunotechnology : an international journal of immunological engineering, 1999A novel technology in the area of antibody engineering has been developed which allows for the creation of new types of antibody molecules. It is called complementarity-determining region (CDR) implantation and permits the random combination of CDR sequences formed in vivo into a single master framework.
E, Söderlind, M, Ohlin, R, Carlsson
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