Results 81 to 90 of about 898,423 (293)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Is complementation a universal strategy? A cross-linguistic corpus study

Linguistic Typology at the Crossroads
This article examines the question of whether complementation structures are cross-linguistically universal by using two different cross-linguistic corpora, each drawing on the same thirteen languages, spanning every continent.
Nicholas Evans, Danielle Barth, I Wayan Arka, Henrik Bergqvist, Christian Döhler, Sonja Gipper, Yukinori Kimoto, Dominique Knuchel, Daniel Majchrzak, Hitomi Ono, Eka Pratiwi, Saskia van Putten, Andrea C. Schalley, Asako Shiohara, Stefan Schnell, Yanti   +15 more
doaj   +1 more source

Levels of Reality

Languages, 2019
Two fundamental aspects of conceptual and linguistic structure are examined in relation to one another: organization into strata, each a baseline giving rise to the next by elaboration; and the conceptions of reality implicated at successive levels of ...
Ronald W. Langacker
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Whys and Wherefores: The Aetiology of the Left Periphery (With Reference to Vietnamese)

Languages
This paper offers a detailed description of the left periphery of embedded clauses in Vietnamese. Five kinds of pre-subject constituent are considered in isolation, and in interaction with one another: subordinating conjunctions; embedded topics; fronted
Nigel Duffield
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Mitochondrial Heterogeneity

Frontiers in Genetics, 2019
Cell-to-cell heterogeneity drives a range of (patho)physiologically important phenomena, such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly of mitochondria, is increasingly being recognized as an important ...
Juvid Aryaman, Juvid Aryaman, Juvid Aryaman, Iain G. Johnston, Iain G. Johnston, Nick S. Jones, Nick S. Jones   +6 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Amélioration de la valeur alimentaire de la paille de riz par le traitement à l'urée et la complémentation en céréales chez le mouton Peulh sénégalais [PDF]

Tropicultura, 1997
Improvement of the Nutritive Value of the Rice Straw by Urea Treatment and Cereals Complementation. Four male peulh sheeps were used in series of experimentation. In the first experiment, the sheeps were fed with rice straw without treatment.
Gongnet, GP., Fadiga, S., Cisse, M.
doaj