Results 81 to 90 of about 205,503 (295)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

FISHING FOR COMPLEMENTS

open access: yesNagoya Mathematical Journal
Abstract Given a presilting object in a triangulated category, we find necessary and sufficient conditions for the existence of a complement. This is done both for classic (pre)silting objects and for large (pre)silting objects. The key technique is the study of associated co-t-structures.
LIDIA ANGELERI HÜGEL   +2 more
openaire   +3 more sources

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Irrealis, aspect, and complementation in Old Javanese

open access: yesWacana: Journal of the Humanities of Indonesia, 2018
This article focuses on two issues in the study of the syntax and semantics of the Old Javanese: (1) the effects of irrealis on the marking of the “passive” or Undergoer Voice verb phrases of Old Javanese, and (2) the study of complementation in Old ...
Thomas M. Hunter
doaj   +1 more source

Generalized complementation

open access: yesJournal of Combinatorial Theory, Series B, 1987
Certain simple phenomena of graph complementation -- selfcomplementarity and semivalidity (truth in every graph or its complement) -- can be ``lifted'' to the natural generalization of complementation involving three-coloring the edges of complete graphs. An additional assumption is needed that no tricolored triangles occur.
openaire   +3 more sources

The complement system

open access: yesCell and Tissue Research, 2010
The complement system consists of a tightly regulated network of proteins that play an important role in host defense and inflammation. Complement activation results in opsonization of pathogens and their removal by phagocytes, as well as cell lysis.
Peter A. Ward, J. Vidya Sarma
openaire   +4 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

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