Results 101 to 110 of about 525,238 (287)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Sensor-based complete coverage path planning in dynamic environment for cleaning robot
CAAI Transactions on Intelligence Technology, 2018 Using Complete Coverage Path Planning (CCPP), a cleaning robot could visit every accessible area in the workspace. The dynamic environment requires the higher computation of the CCPP algorithm because the path needs to be replanned when the path might ...
Hong Liu, Jiayao Ma, Weibo Huang
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Voluntary pension system challenge of expanding coverage [PDF]
Since 1947, the Vietnam Social Security (VSS) has provided social insurance to public servants and armed forces personnel in Vietnam. In 1995, the Government merged the social insurance unit of the Ministry of labour, invalids and social affairs with ...
Castel, Paulette, Phuong, Nguyen Thi Thu
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Complete coverage path planning in an agricultural environment
, 2011 The problem of finding a collision-free path through a region has garnered a lot of research over the years. One branch of this is the problem of finding a path that completely covers a region.
Driscoll, Theresa
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Full Coverage for Minor, Recurrent Losses? [PDF]
This note looks at insurance of minor, recurrent losses. The main concern is with efficiency properties of full coverage. As motivation and running example we concider a regime, currently operative in several European countries, that offers employees ...
Flåm, Sjur Didrik
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Multi-Robot Complete Coverage Using Directional Constraints
, 2018 Complete coverage relies on a path planning algorithm that will move one or more robots, including the actuator, sensor, or body of the robot, over the entire environment. Complete coverage of an unknown environment is used in applications like automated
Malan, Stefanus
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