Results 71 to 80 of about 397,867 (315)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Characterization of Graphs Associated with Numerical Semigroups
Mathematics, 2019 Let Γ be a numerical semigroup. We associate an undirected graph G ( Γ ) with a numerical semigroup Γ with vertex set { v i : i ∈ N \ Γ } and edge set { v i v j ⇔ i + j ∈ Γ }
Muhammad Ahsan Binyamin +4 more
doaj +1 more source
Discrete Applied Mathematics, 1990 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hammer, Peter L., Maffray, Frédéric
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A Ramsey-Theory-Based Approach to the Dynamics of Systems of Material Points
DynamicsWe propose a Ramsey-theory-based approach for the analysis of the behavior of isolated mechanical systems containing interacting particles. The total momentum of the system in the frame of the center of masses is zero.
Edward Bormashenko, Nir Shvalb
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The external field effect on the opinion formation based on the majority rule and the q-voter models on the complete graph [PDF]
, 2022 Azhari Hasibuan, Roni Muslim
openalex +1 more source
Linear Algebra and its Applications, 2016 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Shaked-Monderer, Naomi +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source