Results 111 to 120 of about 49,191 (262)
Lifting fixed points of completely positive mappings
Journal of Mathematical Analysis and Applications, 2009 Let \(1\leq n\leq\infty\) and \(\{T_{j}\}_{j=1}^{n}\subset\mathcal{B}(\mathcal{H})\) be a row contraction on a Hilbert space \(\mathcal{H}\). Let \(\mathcal{F}(T)\) be the space of all \(X\in \mathcal{B}(\mathcal{H})\) such that \(\sum_{j=1}^{n} T_{i}XT_{j}^{*}=X\).
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
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Frontiers in OphthalmologyBackgroundTo introduce a new, simple, and affordable technique that uses a 22G intravenous (I.V.) catheter connected to the vitreotome aspiration to lift the intraocular lens (IOLs) off the retina.MethodsThis retrospective, non-comparative, single ...
Ruiping Gu +14 more
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Geometric topological completions with universal final lifts
Topology and its Applications, 1985 Concrete categories are characterized which have a topological extension with certain universal final lifts and certain trivial fibres. The characterization is closely related to that of the reviewer and \textit{V. Koubek} [ibid. 11, 1-16 (1980; Zbl 0423.18010)] concerning Cartesian closed topological extensions.
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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