Results 91 to 100 of about 683,768 (364)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Related fixed point theorems on two complete and compact metric spaces
International Journal of Mathematics and Mathematical Sciences, 1998 A new related fixed point theorem on two complete metric spaces is obtained. A generalization is given for two compact metric spaces.
R. K. Namdeo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
New Results of Fixed-Point Theorems and Their Applications in Complete Complex Dc∗-Metric Spaces
Journal of Function SpacesThe first objective of the present manuscript is to introduce the notion of complex-valued Dc∗-metric spaces as generalizing and improving the idea of D∗-metric spaces by using the context of complex-valued metric space and D∗-metric spaces.
Nassar Aiman Majid +3 more
doaj +1 more source
Tripled best proximity point in complete metric spaces
Open Mathematics, 2020 In this paper, we introduce a new type of contraction to seek the existence of tripled best proximity point results. Here, using the new contraction and P-property, we generalize and extend results of W. Shatanawi and A. Pitea and prove the existence and
Rohen Yumnam, Mlaiki Nabil
doaj +1 more source
Fixed Point Theory in -Complete Metric Spaces with Applications
, 2014 The aim of this paper is to introduce new concepts of --complete metric space and --continuous function and establish fixed point results for modified ---rational contraction mappings in --complete metric spaces.
N. Hussain, M. Kutbi, P. Salimi
semanticscholar +1 more source
Completing graphs to metric spaces [PDF]
Contributions to Discrete Mathematics, 2017 We prove that certain classes of metrically homogeneous graphs omitting triangles of odd short perimeter as well as triangles of long perimeter have the extension property for partial automorphisms and we describe their Ramsey expansions.
Aranda, Andrés +7 more
openaire +4 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
A Characterization of Complete Metric Spaces [PDF]
Proceedings of the American Mathematical Society, 1981 A general formulation of the completeness argument used in the Bishop-Phelps Theorem and many other places has been given by Ekeland. It is shown that Ekeland's formulation characterizes complete metric spaces. A central idea in the proof of the Bishop-Phelps Theorem is the use of norm completeness and a partial ordering to produce a point where a ...
openaire +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source