Results 71 to 80 of about 23,512 (262)

On the Yoneda completion of a quasi-metric space

Theoretical Computer Science, 2002
The authors consider two notions for the completion of rather general classes of topological spaces: the Yoneda completion of generalized metric spaces and the Smyth completion. (Such considerations are motivated in part by earlier efforts to reconcile continuous domain theory and metric space theory within a common framework.) A net-theoretic version ...
Hans-Peter A. Künzi, Michel P. Schellekens   +1 more
openaire   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Coupled fixed point results on metric spaces defined by binary operations

Karpatsʹkì Matematičnì Publìkacìï, 2018
In parallel with the various generalizations of the Banach fixed point theorem in metric spaces, this theory is also transported to some different types of spaces including ultra metric spaces, fuzzy metric spaces, uniform spaces, partial metric spaces, $
A. Karami, R. Shakeri, S. Sedghi, І. Altun   +3 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Generalizations of Caristi Kirk's Theorem on Partial Metric Spaces

Fixed Point Theory and Applications, 2011
In this article, lower semi-continuous maps are used to generalize Cristi-Kirk's fixed point theorem on partial metric spaces. First, we prove such a type of fixed point theorem in compact partial metric spaces, and then generalize to complete partial ...
Karapinar Erdal
doaj  

Invariant idempotent measures

Karpatsʹkì Matematičnì Publìkacìï, 2018
The idempotent mathematics is a part of mathematics in which arithmetic operations in the reals are replaced by idempotent operations. In the idempotent mathematics, the notion of idempotent measure (Maslov measure) is a counterpart of the notion of ...
N. Mazurenko, M. Zarichnyi
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Quasicone Metric Spaces and Generalizations of Caristi Kirk's Theorem

Fixed Point Theory and Applications, 2009
Cone-valued lower semicontinuous maps are used to generalize Cristi-Kirik's fixed point theorem to Cone metric spaces. The cone under consideration is assumed to be strongly minihedral and normal.
Karapinar Erdal, Abdeljawad Thabet
doaj  

Common Fixed-Point Theorems in Complete Generalized Metric Spaces

Journal of Applied Mathematics, 2012
We introduce the notions of the 𝒲 function and 𝒮 function, and then we prove two common fixed point theorems in complete generalized metric spaces under contractive conditions with these two functions.
Chi-Ming Chen
doaj   +1 more source