Results 91 to 100 of about 331,737 (281)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Generalizations of Caristi Kirk's Theorem on Partial Metric Spaces

open access: yesFixed Point Theory and Applications, 2011
In this article, lower semi-continuous maps are used to generalize Cristi-Kirk's fixed point theorem on partial metric spaces. First, we prove such a type of fixed point theorem in compact partial metric spaces, and then generalize to complete partial ...
Karapinar Erdal
doaj  

Coupled fixed point results on metric spaces defined by binary operations

open access: yesKarpatsʹkì Matematičnì Publìkacìï, 2018
In parallel with the various generalizations of the Banach fixed point theorem in metric spaces, this theory is also transported to some different types of spaces including ultra metric spaces, fuzzy metric spaces, uniform spaces, partial metric spaces, $
A. Karami   +3 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Quasicone Metric Spaces and Generalizations of Caristi Kirk's Theorem

open access: yesFixed Point Theory and Applications, 2009
Cone-valued lower semicontinuous maps are used to generalize Cristi-Kirik's fixed point theorem to Cone metric spaces. The cone under consideration is assumed to be strongly minihedral and normal.
Karapinar Erdal, Abdeljawad Thabet
doaj  

Invariant idempotent measures

open access: yesKarpatsʹkì Matematičnì Publìkacìï, 2018
The idempotent mathematics is a part of mathematics in which arithmetic operations in the reals are replaced by idempotent operations. In the idempotent mathematics, the notion of idempotent measure (Maslov measure) is a counterpart of the notion of ...
N. Mazurenko, M. Zarichnyi
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Common Fixed-Point Theorems in Complete Generalized Metric Spaces

open access: yesJournal of Applied Mathematics, 2012
We introduce the notions of the 𝒲 function and 𝒮 function, and then we prove two common fixed point theorems in complete generalized metric spaces under contractive conditions with these two functions.
Chi-Ming Chen
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

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