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Integrative annotation of 21,037 human genes validated by full-length cDNA clones
, 2004 The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited.Terwilliger Joseph D, Nagata, Naoki, Kuryshev, Vladimir, Eveno, E., Imbeaud, S., Makalowski, W., Yoshiyuki Suzuki, Sakai, Katsunaga, Graudens Esther, de Souza, S.J., Sakamoto Shigetaka, Thomas, M.A., Ashurst, Jennifer, Kanehisa Minoru, Shinsei Minoshima, Korn, B., Mitsuteru Nakao, Robert L Strausberg, Unneberg, P., Eveno Eric, Ren, S. -X, Lenhard, B., Shiba, Rie, Hilton Phillip, Sakate, Ryuichi, Bromberg Susan K, Gopal R. Gopinath, Nakai, K., Jia, Libin, Alexander Kanapin, Momoki Hirai, Barrero, R., Strausberg Robert L, Steward Charles, Suzuki, Yutaka, Okazaki, Yasushi, Makalowski Wojciech, Okido Toshihisa, Fukami-Kobayashi Kaoru, Satoshi Oota, Motohiko Tanino, Hide, Winston, R. Gopinath, Gopal, Auffray, C., de Souza, S., Shimoyama, Mary, Dubchak Inna, Osamu Ogasawara, Erimi Harada, Quackenbush, John, Jun-ichi Takeda, Steward, C., Kikuno, Reiko, Hirai, M., Isogai, T., Piero Carninci, Matsuda, Hideo, Ryuichi Sakate, Suzuki Yutaka, Kenta Nakai, Chen Zhu, Hiroaki Sakai, Shiba, R., Okubo, K., Nomura Nobuo, Sandro J. de Souza, Taylor Todd, Toshihisa Takagi, Thierry-Mieg Jean, Fukuchi Satoshi, Nagasaki, H., Hayashizaki, Yoshihide, Bellgard Matthew, Chelala Claude, Terwilliger, J., Bruford Elspeth, Apweiler Rolf, Christine Couillault, Takeya Kasukawa, Suzuki Mami, Nobuo Nomura, Sakai Katsunaga, Korn, Bernhard, Mulder, N., Amid, Clara, Schupp, Ingo, Kasukawa Takeya, Veeramachaneni, V., Wagner, L., Yura Kei, Annemarie Poustka, Yura, Kei, Ian Hopkinson, Hashimoto, Katsuyuki, Bono, H., Endo, T., Couillault, Christine, Elspeth Bruford, Bono Hidemasa, Ota Toshio, Reiko Kikuno, O'Donovan, C., Ota, M., Jia, L., Han Michael, Okazaki, Y., Shuang-Xi Ren, Tamura, T., Sakamoto, S., Bromberg, Susan K., Ohara, Osamu, Korn Bernhard, Hyang-Yoo, S., Nagata, N., Karavidopoulou Youla, Koyanagi, K.O., Soares, Bento, Tanaka, H., Charles Steward, Yamasaki, Chisato, Saitou Naruya, Yoo, H-S, Norikazu Yasuda, Imbeaud, Sandrine, Roberto A Barrero, Nishikawa Tetsuo, Izabela Makalowska, Jin Lihua, Nigam, Rajni, Gopinath, G. R., Motonori Ota, Stephen Sherry, Hiroshi Tanaka, Yayoi Kaneko, Jean Thierry-Mieg, Okada, Norihiro, Kelso, J. ; https://orcid.org/, Fukami-Kobayashi, K., Otsuki, Tetsuji, Yura, K., Ikeo, K., Hanaoka, Hideki, Rajni Nigam, Tanino, Motohiko, Sugano Sumio, Matthew Bellgard, Kaoru Fukami-Kobayashi, Oota Satoshi, Shimizu, Nobuyoshi, Sugano, Sumio, Satoshi Fukuchi, O'Donovan, Claire, Ren, S-X, Todd Taylor, Kimura Kouichi, Bonaldo, Maria de Fatima, Poustka, Annemarie, Koyanagi, K., Shimizu, N., Kanapin Alexander, Bono, Hidemasa, Chelala, Claude, Koyanagi, Kanako O., Devignes, M. -D, Stodolsky, M., Brookes, A., Strausberg, R., Danielle Thierry-Mieg, Stefan Wiemann, Eyras, Eduardo, Brookes, Anthony J., Mami Suzuki, Lukas Wagner, Hilton, Phillip, Barrero Roberto A, Suzuki Yoshiyuki, Sugawara Hideaki, Kasukawa, T., Yoshihide Hayashizaki, Mano, Shuhei, Craig Gough, Takashi Makino, Takahashi, Aiko, Shuhei Mano, Takashi Gojobori, Suzuki, Yoshiyuki, Libin Jia, Kousaku Okubo, Han, Michael, Koyanagi Kanako O, Hidemasa Bono, Inoko, Hidetoshi, Hinz Ursula, Auffray Charles, Strausberg, R.L., Yamaguchi-Kabata, Y., Devignes, Marie Dominique, Norihiro Okada, Hideki Hanaoka, Oota, S., Fujii Yasuyuki, Han, Ze-Guang, Isogai Takao, Kasprzyk, A., Ranajit Chakraborty, Itoh, Takeshi, Terwilliger, Joseph D., Florence Servant, Mulder, Nicola, Takahashi, A., Piatier-Tonneau, Dominique, Hirakawa Mika, R. Gopinath, G., Bromberg, S., Hinz, Ursula, Suwa Makiko, Hopkinson, I., Thierry-Mieg Danielle, Chelala, C., Mewes, Hans Werner, Amid, C., Hirakawa, Mika, Servant, Florence, Hishiki, T., Nomura, N., Steward, Charles, Tamiya, G., Rie Shiba, Hahn Yoonsoo, Fujii, Y., Tateno Yoshio, Sugawara, H., Ren, Shuang Xi, Naoki Nagata, Soares Bento, Hidetoshi Inoko, Sakai, H., Schupp, I., Sakamoto, Shigetaka, Lenhard Boris, Yasuda Norikazu, Nakai Kenta, Kim, S., Kersey Paul, Watanabe Shinya, de Bonaldo, M., Hishiki, Teruyoshi, Mariage-Samson, R., Toshinori Endo, Hishiki Teruyoshi, Bellgard, Matthew, Mano, S., Nishikawa, Tetsuo, Okido, T., Wiemann, S., Anne Estreicher, Hayashizaki, Y., Miyazaki, Satoru, Susan K Bromberg, Apweiler, R., Katsunaga Sakai, Han, M., Oishi Michio, Hide, W., Kanako O Koyanagi, Tetsuo Nishikawa, Nobuyoshi Shimizu, Carninci, Piero, Makino Takashi, Dubchak, Inna, Yoo, Hyang-Sook, Ren, S., Strausberg, R. L., Estreicher, A., Yamasaki Chisato, Eyras, E., Tanaka Hiroshi, Nagai, Keiichi, Wilming, Laurens, Phillip Hilton, Ota, T., Go, M., Wilming Laurens, Winston Hide, Hopkinson Ian, Yasuda, Norikazu, Graudens, Esther, Regine Mariage-Samson, Harada, Erimi, Suwa, Makiko, Claude Chelala, Sherry Stephen, Yamaguchi-Kabata, Yumi, Eduardo Eyras, Han, Z. -G, Chakraborty, Ranajit, Teruyoshi Hishiki, Yoo, H-S., Mariage-Samson, Regine, Piatier-Tonneau Dominique, Kim, Sangsoo, Takeda, Jun Ichi, Bento Soares, Poustka, A., Zhu Chen, Makalowska, Izabela, Okada, N., Youla Karavidopoulou, Amid Clara, Suzuki, M., Sakai, K., Unneberg, Per, Wiemann Stefan, Inna Dubchak, Taylor, T., Okido, Toshihisa, Charles Auffray, Kelso, J., Hirai Momoki, Jennifer Ashurst, Yasuyuki Fujii, Nigam, R., Nishikawa, Ken, Terwilliger, J.D., Gopal R Gopinath, Tetsuji Otsuki, Nakao Mitsuteru, Brookes Anthony J, Hahn, Y., Simpson, A.J., Debily, Marie-Anne, Sangsoo Kim, Imanishi Tadashi, Homma, Keiichi, Kasukawa, Takeya, Makalowska Izabela, Takeda, J-I, Yutaka Suzuki, Jin, Lihua, Terwilliger, J. D., Aiko Takahashi, Hyang-Yoo, Sook, Sakai Hiroaki, Shimizu Nobuyoshi, Michael A Thomas, Tadashi Imanishi, Esther Graudens, Paul Kersey, Stodolsky Marvin, Toshio Ota, Ren, Shuang-Xi, Carninci Piero, Tanaka, S., Imanishi, T., Yoshio Tateno, Simpson Andrew J, de Fatima Bonaldo, Maria, Yoo Hyang-Sook, Imbeaud Sandrine, Brookes, A.J., Kikuno Reiko, Tanaka, Susumu, Tamiya, Gen, de Souza Sandro J., Sugano, S., Tomohiro Yasuda, Wilming, L., Keiichi Nagai, Devignes, Marie-Dominique, Matsuda Hideo, Takeda, J. -I, Nishikawa, T., Thierry-Mieg, J., Hideki Nagasaki, Estreicher Anne, Harada, E., Ota, Toshio, Yumi Yamaguchi-Kabata, Kelso, Janet, Minoshima Shinsei, Tanaka, Hiroshi, Kimura, K., Ingo Schupp, Sumio Sugano, Piatier-Tonneau, D., Yasuda, T., Simpson, A. J., Minoru Kanehisa, Ren Shuang-Xi, Janet Kelso, Barrero, R.A., Eyras Jiménez, Eduardo, Kaneko Yayoi, Servant, F., Hideaki Sugawara, Tamura Takuro, Susumu Tanaka, Tonellato, Peter, Gopinath, Gopal R., Thomas Michael A, Poustka Annemarie, Sugawara, Hideaki, Sakai, Hiroaki, Nagata Naoki, Dominique Piatier-Tonneau, Gojobori Takashi, Oishi, M., Nagai Keiichi, Chisato Yamasaki, Koyanagi, K. O., Thomas, M. A., Ohtsubo, Masafumi, Shigetaka Sakamoto, Hanada Kousuke, Fukuchi, S., Andrew J Simpson, Chakraborty Ranajit, Sakate, R., Mewes Hans-Werner, Matsuda, H., Kaneko, Yayoi, Kasprzyk Arek, Hashimoto, K., Otsuki, T., Ursula Hinz, Keiichi Homma, Bellgard, M., Harada Erimi, Tanino Motohiko, Minoshima, Shinsei, R. Gopinath Gopal, Joseph D Terwilliger, Souza, Sandro J. de, Gopinath, G., Oota, Satoshi, Debily Marie-Anne, Kanapin, Alexander, Karavidopoulou, Y., De Fatima Bonaldo, M., Isogai, Takao, Per Unneberg, Okazaki Yasushi, Takeshi Itoh, Fukami-Kobayashi, Kaoru, Yoonsoo Hahn, Peter Tonellato, Hirakawa, M., Jin, L., Makino, Takashi, Thierry-Mieg, D., Brookes, A. J., Ohara Osamu, Gopinath, G.R., Takahashi Aiko, Bernhard Korn, Watanabe, S., Kazuho Ikeo, Takao Isogai, Okubo Kousaku, Unneberg, Per,, Souza, S., Yoshiyuki Sakaki, Ashurst, J., Michael Han, Kanehisa, Minoru, Gojobori, T., Barrero, R. A., de Souza, S. J., Sandrine Imbeaud, Bruford, Elspeth, Bromberg, S. K., Shimoyama, M., Makalowska, I., Simpson, A., Laurens Wilming, Devignes, M., Karavidopoulou, Youla, Han, Z-G., Otsuki Tetsuji, Hopkinson, Ian, Itoh Takeshi, Claire O'Donovan, Ogasawara, Osamu, Nakai, Kenta, Jia Libin, Okubo, Kousaku, Eveno, Eric, Shimoyama Mary, Unneberg Per, Hyang-Sook Yoo, Estreicher, Anne, Veeramachaneni, Vamsi, Servant Florence, Hans-Werner Mewes, Sakaki, Yoshiyuki, Quackenbush John, Sherry, S., Masafumi Ohtsubo, Veeramachaneni Vamsi, Kikuno, R., Wagner Lukas, Mika Hirakawa, Schupp Ingo, Vamsi Veeramachaneni, Ikeo Kazuho, Apweiler, Rolf, Kasprzyk, Arek, Sherry, Stephen, Takeda, J., Thierry-Mieg, Jean, Devignes Marie-Dominique, Eric Eveno, Nagai, K., Marie-Anne Debily, Yasuda, N., Mashima Jun, Carninci, P., Naruya Saitou, Shinya Watanabe, Mashima, J., Nakao, M., Satoru Miyazaki, Ohtsubo, M., Saitou, N., O'Donovan Claire, John Quackenbush, Kuryshev Vladimir, Miyazaki Satoru, Nishikawa, K., Nigam Rajni, Takagi, T., Han, Z., Kuryshev, V., Couillault, C., Yamaguchi-Kabata Yumi, Tamura, Takuro, Simpson, Andrew J., Watanabe, Shinya, Tanino, M., Tateno, Y., Hanaoka Hideki, Takagi, Toshihisa, Soares, B., Mulder Nicola, Mewes, H. -W, Bonaldo Maria de Fatima, Suzuki, Mami, Ikeo, Kazuho, Oishi, Michio, Mitiko Go, Lenhard, Boris, Okada Norihiro, Go, Mitiko, Homma Keiichi, Ota Motonori, Quackenbush, J., Nicola Mulder, Bromberg, S.K., Takeda Jun-ichi, Kersey, P., Rolf Apweiler, Suzuki, Y., Boris Lenhard, Vladimir Kuryshev, Hinz, U., Kanapin, A., Kei Yura, Saitou, Naruya, Chakraborty, R., Debily, Marie Anne, Ogasawara Osamu, Wagner, Lukas, Mewes, Hans-Werner, Taylor, Todd, Hanaoka, H., Gen Tamiya, Thomas, M., Miyazaki, S., Takuro Tamura, Kaneko, Y., Yasuda Tomohiro, Minoshima, S., Sakaki Yoshiyuki, Tanaka Susumu, Mano Shuhei, Yoo, H., Suwa, M., Ze-Guang Han, Tamiya Gen, Kouichi Kimura, Hashimoto Katsuyuki, Barrero, Roberto A., Sakaki, Y., Dubchak, I., Chen, Z., Debily, M., Fukuchi, Satoshi, Toshihisa Okido, Gough Craig, Fujii, Yasuyuki, Nishikawa Ken, Makiko Suwa, Nomura, Nobuo, Kersey, Paul, Auffray, Charles, Clara Amid, Sandro J de Souza, Gough, Craig, Shiba Rie, Tonellato, P., Mashima, Jun, Osamu Ohara, Wiemann, Stefan, Graudens, E., Ohara, O., Hanada, Kousuke, Endo Toshinori, Ohtsubo Masafumi, Sakate Ryuichi, Wojciech Makalowski, Homma, K., Hahn, Yoonsoo, Bruford, E., Gough, C., Go Mitiko, Yasuda, Tomohiro, Hirai, Momoki, Chen, Zhu, Nagasaki Hideki, Yasushi Okazaki, Imanishi, Tadashi, Nakao, Mitsuteru, Kimura, Kouichi, Nagasaki, Hideki, Mewes, H., Strausberg, Robert L., Hide Winston, Debily, M. -A, Stodolsky, Marvin, Kousuke Hanada, Thierry-Mieg, Danielle, Mewes, H-W, de Souza, Sandro J., Lihua Jin, Thomas, Michael A., Mary Shimoyama, Katsuyuki Hashimoto, Kim Sangsoo, Hayashizaki Yoshihide, Hilton, P., Anthony J Brookes, Mariage-Samson Regine, Jun Mashima, Ken Nishikawa, Takeda, Jun-ichi, Ashurst Jennifer, Yamasaki, C., Inoko, H., Makino, T., Arek Kasprzyk, Gojobori, Takashi, Makalowski, Wojciech, Hanada, K., Kanehisa, M., Couillault Christine, Michio Oishi, Eyras Eduardo, Marie-Dominique Devignes, Tateno, Yoshio, Tonellato Peter, Takagi Toshihisa, Marvin Stodolsky, Endo, Toshinori, Itoh, T., Bonaldo, M., Maria de Fatima Bonaldo, Han, Ze Guang, Ota, Motonori, Han Ze-Guang, Hideo Matsuda, Inoko Hidetoshi, Ogasawara, O., Kelso Janet +682 morecore +1 more sourceTME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy
Advanced Science, EarlyView.A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song +17 morewiley +1 more sourceBIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation
Advanced Science, EarlyView.Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong +10 morewiley +1 more sourceCrystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity
Advanced Science, EarlyView.Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang +10 morewiley +1 more sourceThe complete mitochondrial genome of Pontederia crassipes: using HiFi reads to investigate genome recombination and gene transfer from chloroplast genome
Frontiers in Plant ScienceWater hyacinth (Pontederia crassipes Mart.) is a monocotyledonous aquatic plant renowned for its rapid growth, extensive proliferation, biological invasiveness, and ecological resilience to variations in pH, nutrients, and temperature.Zhigang Hao, Xiaoqi Jiang, Lei Pan, Jingyuan Guo, Yi Chen, Jianqiang Li, Biao Liu, Anping Guo, L. Luo, Ruizong Jia +9 moresemanticscholar +1 more sourcetBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls
Advanced Science, EarlyView.We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei +11 morewiley +1 more source
