Results 121 to 130 of about 167,627 (310)

Characterization of the complete mitochondrial genome and phylogenetic analyses of Haemaphysalis tibetensis Hoogstraal, 1965 (Acari: Ixodidae).

Ticks and Tick-borne Diseases
Ticks are specialized ectoparasites that feed on blood, causing physical harm to the host and facilitating pathogen transmission. The genus Haemaphysalis contains vectors for numerous infectious agents.
Wenqiang Tang, Xin Li, Bijin Ye, Bin Shi, Haoji Zhang, Zhisheng Dang, Yue Sun, Lamu Danqu, Chenyang Xia, Danzeng Quzhen, Xia-ling Zhao, Wenting Chui, Fuqiang Huang   +12 more
semanticscholar   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies

Disease Models & Mechanisms, 2015
Mitochondrial diseases are severe and largely untreatable. Owing to the many essential processes carried out by mitochondria and the complex cellular systems that support these processes, these diseases are diverse, pleiotropic, and challenging to study.
Jean-Paul Lasserre, Alain Dautant, Raeka S. Aiyar, Roza Kucharczyk, Annie Glatigny, Déborah Tribouillard-Tanvier, Joanna Rytka, Marc Blondel, Natalia Skoczen, Pascal Reynier, Laras Pitayu, Agnès Rötig, Agnès Delahodde, Lars M. Steinmetz, Geneviève Dujardin, Vincent Procaccio, Jean-Paul di Rago   +16 more
doaj   +1 more source

Desenvolvimento de um protocolo de isolamento de cloroplastos e DNA plastidial em coníferas e sequenciamento do genoma plastidial de Podocarpus lambertii Klotzch ex Endl. [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Recursos Genéticos Vegetais, Florianópolis, 2014.O sequenciamento do genoma plastidial de coníferas vem sendo realizado por meio do
Vieira, Leila do Nascimento
core  

De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis [PDF]

, 2010
Filamentous fungi are of great importance in ecology, agriculture, medicine, and biotechnology. Thus, it is not surprising that genomes for more than 100 filamentous fungi have been sequenced, most of them by Sanger sequencing.
Kück Ulrich, Espagne, Eric, Jason E Stajich, Kempken, Frank, Ines Engh, Stefanie Pöggeler, Frank Kempken, Ulrich Kück, Kuo, Hsiao Che, Jens Kamerewerd, Osiewacz, Heinz D., Zickler, Denise, Espagne Eric, Kück, Ulrich, Engh Ines, Freitag, Michael H., Smith, Kristina M, Meiling Chu, Chu Meiling, Smith Kristina M., Kuo, Hsiao-Che, Read, Nick D, Heinz D Osiewacz, Kempken Frank, Poeggeler, Stefanie, Knab, Birgit, Birgit Knab, Denise Zickler, Kuo Hsiao-Che, Kueck, Ulrich, Stajich Jason E., Osiewacz, Heinz D, Stajich, Jason E, Michael Freitag, Stephan Seiler, Halliday, Karen, Freitag, Michael, Stajich, Jason E., Chu, Meiling, Nick D Read, Karen Halliday, Knab Birgit, Zickler Denise, Kristina M Smith, Pöggeler, Stefanie, Engh, Ines, Eric Espagne, Hsiao-Che Kuo, Kamerewerd Jens, Smith, Kristina M., Halliday Karen, Pöggeler Stefanie, Seiler Stephan, Read Nick D., Nowrousian, Minou, Seiler, Stephan, Osiewacz Heinz D., Freitag Michael, Nowrousian Minou, Read, Nick D., Kamerewerd, Jens, Minou Nowrousian   +61 more
core   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures

Communications Biology, 2019
Antarctic fish belonging to Notothenioidei represent an extraordinary example of radiation in the cold. In addition to the absence of hemoglobin, icefish show a number of other striking peculiarities including large-diameter blood vessels, high vascular ...
L. Bargelloni, M. Babbucci, S. Ferraresso, C. Papetti, N. Vitulo, R. Carraro, M. Pauletto, G. Santovito, M. Lucassen, F. Mark, L. Zane, T. Patarnello   +11 more
semanticscholar   +1 more source

Trophic Diversity in Duckweed: Mixotrophy, More Than the Sum of its Extremes

Advanced Science, EarlyView.
In the context of rising DOC in aquatic environments, mixotrophic duckweed may impact carbon cycling by acting as either a carbon sink, as they absorb CO2 through photosynthesis, or a carbon source, as they release CO2 through respiration of absorbed DOC, which depends on DOC concentration, light availability, temperature, and other environmental ...
Zuoliang Sun, Yan Chen, Fajun Li, Xuyao Zhao, Qingxiang Han, Hongwei Hou   +5 more
wiley   +1 more source

The complete mitochondrial genome of Sarcophaga (Liosarcophaga) dux (Diptera: Sarcophagidae)

Mitochondrial DNA. Part B. Resources, 2019
Sarcophaga (Liosarcophaga) dux Thomson (Diptera: Sarcophagidae) is a flesh fly species of medical and forensic importance in many parts of the world, both as a fly with the necrophagous habits found on human corpses and a vector of disease or parasitic ...
Yanjie Shang, Li Yang, Lipin Ren, Wei Chen, Xiao Shen, Yadong Guo   +5 more
doaj   +1 more source

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source