Results 161 to 170 of about 294,629 (332)

A method to investigate muscle target‐specific transcriptional signatures of single motor neurons

Developmental Dynamics, Volume 252, Issue 1, Page 208-219, January 2023., 2023
Abstract Background Motor neurons in the vertebrate spinal cord have long served as a paradigm to study the transcriptional logic of cell type specification and differentiation. At limb levels, pool‐specific transcriptional signatures first restrict innervation to only one particular muscle in the periphery, and get refined, once muscle connection has ...
Bianka Berki, Fabio Sacher, Antoine Fages, Patrick Tschopp, Maëva Luxey   +4 more
wiley   +1 more source

The complete sequence of the mitochondrial genome of the Chinook salmon, Oncorhynchus tshawytscha [PDF]

, 2003
V Wilhelm, Jaime Villegas, Alvaro Miquel, Esteban A. Engel, Sebastián Bernales, Pablo Valenzuela, Luis O. Burzio   +6 more
openalex   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Assessing flower‐visiting arthropod diversity in apple orchards through metabarcoding of environmental DNA from flowers and visual census

Environmental DNA, Volume 5, Issue 1, Page 117-131, January 2023., 2023
The diversity of flower‐visiting arthropods in four Danish apple orchards was assessed using molecular (metabarcoding) and non‐molecular techniques. The aim was to obtain a broader overview of arhtropod communities present to support future management practices towards more sustainable agricultural systems.
Nerea Gamonal Gomez, Didde Hedegaard Sørensen, Physilia Ying Shi Chua, Lene Sigsgaard   +3 more
wiley   +1 more source

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, EarlyView.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Automated sequencing of complete mitochondrial genomes from laser-capture microdissected samples [PDF]

, 2003
Beau A. Aldridge, So Dug Lim, Amanda K. Baumann, Seyed Vali Hosseini, Whitney Buck, Tara L. Almekinder, Carrie Sun, John A. Petros   +7 more
openalex   +1 more source

PLXDC1+ Tumor‐Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
This study uncovers the activation, heterogeneity, and regulatory roles of pancreatic stellate cells (PSCs) at single‐cell and spatial levels. It further identifies PLXDC1+ PSCs near aggressive LRRC15+ cancer‐associated myofibroblasts and SPP1+ macrophages, forming a desmoplastic and immunosuppressive tumor niche that promotes CD8+ T cell exhaustion ...
Yanhua Du, Yizhou Zhao, Judong Li, Jiaxin Wang, Shenglan You, Yao Zhang, Li Zhang, Jihong Yang, Hamid Alinejad‐Rokny, Shujie Cheng, Chenghao Shao, Duowu Zou, Youqiong Ye   +12 more
wiley   +1 more source

Exploring the Multifractal Behavior of the Human Genome T2T-CHM13v2.0: Graphical Representations and Cytogenetics [PDF]

arXiv
In this work, we applied the Chaos Game Representation (CGR) to the complete human genomic sequence T2T-CHM13v2.0, analyzing the entire chromosome assembly and each chromosome separately, including mitochondrial DNA. Multifractal spectra were determined using two types of box-counting coverage, revealing slight variations across most chromosomes. While
arxiv  

Determination of the complete nucleotide sequence and haplotypes in the D-loop region of the mitochondrial genome in the Oriental white stork, Ciconia boyciana.

, 2000
Yoshihiro Yamamoto, Koichi Murata, Hideo Matsuda, Takahisa Hosoda, Kazuo Tamura, Jun-ichi Furuyama   +5 more
openalex   +2 more sources

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development

Advanced Science, EarlyView.
The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao, Tianxiang Tang, Bowen Wang, Shengfei He, Yue Zhang, Li Dong, Bo Xu, Ying Liu, Ping Zhu, Rui Guo   +9 more
wiley   +1 more source