Fusion Genes and RNAs in Cancer Development
Non-Coding RNA, 2021 Fusion RNAs are a hallmark of some cancers. They result either from chromosomal rearrangements or from splicing mechanisms that are non-chromosomal rearrangements.
Kenzui Taniue, Nobuyoshi Akimitsu
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DNA topoisomerases participate in fragility of the oncogene RET [PDF]
, 2013 Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
A Ganguly +86 more
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Comparative studies of X chromosomes in Cervidae family
Scientific Reports, 2023 The family Cervidae is the second most diverse in the infraorder Pecora and is characterized by variability in the diploid chromosome numbers among species.
Anastasia A. Proskuryakova +8 more
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The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. [PDF]
, 2014 DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear.
Blaikley, EJ +13 more
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Seven-fluorochrome mouse M-FISH for high-resolution analysis of interchromosomal rearrangements [PDF]
, 2003 The mouse has evolved to be the primary mammalian genetic model organism. Important applications include the modeling of human cancer and cloning experiments. In both settings, a detailed analysis of the mouse genome is essential.
Geigl, J. +3 more
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Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases. [PDF]
PLoS Genetics, 2012 DNA double-strand break (DSB) repair occurring in repeated DNA sequences often leads to the generation of chromosomal rearrangements. Homologous recombination normally ensures a faithful repair of DSBs through a mechanism that transfers the genetic ...
Benjamin Pardo, Andrés Aguilera
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Complex chromosome rearrangements: Report of three patients [PDF]
Japanese journal of human genetics, 1988 Three unrelated patients are described, each with a complex,de novo chromosome rearrangement involving four or more break points. One of the patients had few clinical abnormalities and an apparently balanced karyotype with seven break points (1q32, 2q37, 3q26.2, 5q11.2, 5q15, 6q25, 10p13) in six derivative chromosomes.
T, Kamei +5 more
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Adenoid cystic carcinoma: emerging role of translocations and gene fusions. [PDF]
, 2016 Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis, which reflects the propensity of ACC to progress to clinically advanced metastatic disease.
Brait, Mariana +5 more
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Animals, 2022 Chromosomal rearrangements can directly influence population differentiation and speciation. The Liolaemus monticola complex in Chile is a unique model consisting of several chromosome races arranged in a latitudinal sequence of increasing karyotype ...
Madeleine Lamborot +4 more
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Complex chromosomal rearrangements: origin and meiotic behavior [PDF]
Human Reproduction Update, 2011 Complex chromosomal rearrangements (CCRs) describe structural rearrangements, essentially translocations, involving at least three breakpoints on two or more chromosomes. Although they are rare in humans, their clinical identification is important since CCR carriers can display various phenotypes which include phenotypically normal subjects, infertile ...
F, Pellestor +6 more
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