Results 101 to 110 of about 15,740,088 (326)

Rotational microrheology of Maxwell fluids using micron-sized wires

, 2013
We demonstrate a simple method for rotational microrheology in complex fluids, using micrometric wires. The three-dimensional rotational Brownian motion of the wires suspended in Maxwell fluids is measured from their projection on the focal plane of a ...
Abou, Bérengère, Berret, Jean-François, Chevry, Loudjy, Colin, Rémy   +3 more
core   +3 more sources

The Juicebox Assembly Tools module facilitates de novo assembly of mammalian genomes with chromosome-length scaffolds for under $1000

bioRxiv, 2018
Hi-C contact maps are valuable for genome assembly (Lieberman-Aiden, van Berkum et al. 2009; Burton et al. 2013; Dudchenko et al. 2017). Recently, we developed Juicebox, a system for the visual exploration of Hi-C data (Durand, Robinson et al. 2016), and
O. Dudchenko, M. Shamim, S. Batra, Neva C. Durand, Nathaniel T. Musial, Ragib Mostofa, Melanie Pham, Brian Glenn St Hilaire, Weijie Yao, Elena K. Stamenova, Marie Hoeger, Sarah K Nyquist, Valeriya Korchina, Kelcie Pletch, J. Flanagan, A. Tomaszewicz, D. McAloose, Cynthia Pérez Estrada, Ben J. Novak, Arina D. Omer, Erez Lieberman Aiden   +20 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Growth stanzas in an Epinephelidae-Lutjanidae complex: considerations to length-weight relationships

Revista de Biología Tropical, 2015
Growth stanzas or abrupt changes in growth rates are present throughout the life span of fish. Identifying growth stanzas will help to adequately described growth taking into account that fishes are indeterminate growers.
Ximena Renán, Jorge Trejo-Martínez, Doralice Caballero-Arango, Thierry Brulé   +3 more
doaj  

Inherent structure length in metallic glasses: simplicity behind complexity [PDF]

Scientific Reports, 2015
AbstractOne of the central themes in materials science is the structure-property relationship. In conventional crystalline metals, their mechanical behaviour is often dictated by well-defined structural defects such as dislocations, impurities and twins.
Yuan Wu, Hui Wang, Yongqiang Cheng, Xiongjun Liu, Xidong Hui, Taigang Nieh, Yandong Wang, Zhaoping Lu   +7 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

First-Passage Properties of Bursty Random Walks

, 2010
We investigate the first-passage properties of bursty random walks on a finite one-dimensional interval of length L, in which unit-length steps to the left occur with probability close to one, while steps of length b to the right -- "bursts" -- occur ...
Redner, S., Volovik, D.
core   +1 more source

Complexity of the minimum-length corridor problem

Computational Geometry, 2007
The authors study the minimum-length corridor (MLC) problem and some of its variants. More precisely, given a rectangular boundary partitioned into rectilinear polygons, the problem consists in finding a corridor of least total length. A corridor is a set of line segments each of which must lie along the line segments that form the rectangular boundary
Gonzalez-Gutierrez, Arturo, Gonzalez, Teofilo F.   +1 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source