Results 131 to 140 of about 15,740,088 (326)

The Dryopteris patula complex (Dryopteridaceae) in Mexico: morphometric analyses

Botan‪ical Sciences, 2009
We studied collections from four species of the Dryopteris patula complex (D. cinnamomea, D. patula, D. rosea, and D. rossii) to identify the morphological characters that distinguish them from one another. D. maxonii and D. wallichiana were included as
Victoria Hernández Hernández, Teresa Terrazas, Claudio Delgadillo Moya   +2 more
doaj   +1 more source

Structure and function of the Zika virus full-length NS5 protein

Nature Communications, 2017
The recent outbreak of Zika virus (ZIKV) has infected over 1 million people in over 30 countries. ZIKV replicates its RNA genome using virally encoded replication proteins.
Baoyu Zhao, Guanghui Yi, F. Du, Yin-Chih Chuang, Robert C Vaughan, B. Sankaran, C. Kao, Pingwei Li   +7 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Operator K-complexity in DSSYK: Krylov complexity equals bulk length

Journal of High Energy Physics
Abstract In this paper we study the notion of complexity under time evolution in chaotic quantum systems with holographic duals. Continuing on from our previous work, we turn our attention to the issue of Krylov complexity upon the insertion of a class of single-particle operators in the double-scaled SYK model. Such an operator is
M. Ambrosini, E. Rabinovici, A. Sánchez-Garrido, R. Shir, J. Sonner   +4 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Solid-state NMR of a protein in a precipitated complex with a full-length antibody.

Journal of the American Chemical Society, 2014
NMR spectroscopy is a prime technique for characterizing atomic-resolution structures and dynamics of biomolecular complexes but for such systems faces challenges of sensitivity and spectral resolution.
Jonathan M. Lamley, D. Iuga, Carl Öster, H. Sass, Marco Rogowski, Andres Oss, J. Past, A. Reinhold, S. Grzesiek, A. Samoson, Józef R. Lewandowski   +10 more
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The frequency-dependent neuronal length constant in transcranial magnetic stimulation

Frontiers in Cellular Neuroscience, 2016
Background: The behavior of the dendritic or axonal membrane voltage due to transcranial magnetic stimulation (TMS) is often modeled with the one-dimensional cable equation.
Risto Juhani Ilmoniemi, Hanna Katriina Mäki, Hanna Katriina Mäki, Jukka Saari, Ricardo Salvador, Pedro Cavaleiro Miranda   +5 more
doaj   +1 more source

Cryo-EM structure of the activated GLP-1 receptor in complex with G protein

Nature, 2017
Glucagon-like peptide 1 (GLP-1) is a hormone with essential roles in regulating insulin secretion, carbohydrate metabolism and appetite. GLP-1 effects are mediated through binding to the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor (GPCR)
Yan Zhang, Bingfa Sun, D. Feng, Hongli Hu, M. Chu, Q. Qu, Jeffrey Tarrasch, Shan Li, T. S. Kobilka, B. Kobilka, G. Skiniotis   +10 more
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source