Results 81 to 90 of about 1,340,789 (232)

Turning up the current – optimizing stimulation parameters with vagus nerve stimulation in a nationwide Norwegian cohort (The NOR-current study)

Brain Stimulation
Background: Despite widespread use of vagus nerve stimulation (VNS), evidence regarding optimal stimulation titration and dosing remains limited.
Konstantin Hrisimirov Kostov, Hrisimir Kostov, Pål Gunnar Larsson, Oliver Henning, Arild Egge, Morten Ingvar Lossius, Jukka Peltola   +6 more
doaj   +1 more source

Crowdsourced Quantification and Visualization of Urban Mobility Space Inequality

Urban Planning, 2018
Most cities are car-centric, allocating a privileged amount of urban space to cars at the expense of sustainable mobility like cycling. Simultaneously, privately owned vehicles are vastly underused, wasting valuable opportunities for accommodating more ...
Michael Szell
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor

Scientific Reports, 2017
Glucocorticoids (GCs)—ligands of the glucocorticoid receptor (GR)—are widely used to treat inflammatory diseases, but suffer from significant side effects and poor responsiveness in certain patient populations.
Xiaofeng Jiang, Amber Dahlin, Scott T. Weiss, Kelan Tantisira, Quan Lu   +4 more
doaj   +1 more source

Centers of complex networks

Journal of Theoretical Biology, 2003
The central vertices in complex networks are of particular interest because they might play the role of organizational hubs. Here, we consider three different geometric centrality measures, excentricity, status, and centroid value, that were originally used in the context of resource placement problems.
Wuchty, Stefan, Stadler, Peter F.
openaire   +4 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

HIV Social-network intervention more effective in older populations in Kenya

BMC Public Health
US President’s Emergency Plan for HIV/AIDS has been credited with saving 25 million lives in sub-Sahara Africa and, as such, constitutes a preeminent US foreign policy achievement of the twenty-first century.
Daniel E. Zoughbie, Dillon Huddleston, Kathleen Watson, Eric L. Ding   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

When dialects collide: how socioeconomic mixing affects language use

EPJ Data Science
The socioeconomic background of people and how they use standard forms of language are not independent, as demonstrated in various sociolinguistic studies.
Thomas Louf, José J. Ramasco, David Sánchez, Márton Karsai   +3 more
doaj   +1 more source

From thread to yarn, and yarn to thread: a complex case of persistent left superior vena cava

Annales Academiae Medicae Silesiensis
Introduction: Persistent left superior vena cava (PLSVC) is a rare venous anomaly, occurring in 0.3–0.5% of the general population and up to 4.3% of patients with heart defects. It forms from the junction of the left subclavian and internal jugular veins,
Julia Dołęga, Natalia Lekston, Karolina Krzywiecka, Aleksandra Machnik, Katarzyna Mizia-Stec   +4 more
doaj   +1 more source