Results 121 to 130 of about 15,651,318 (279)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Evolving hierarchical visually guided neural network agents to investigate complex interactions. [PDF]

, 2008
A complex system is a system with a large number of interacting components without any mechanism for central control that displays self organisation. Understanding how these interactions affect the overall behaviour of a system is of great interest to ...
Schlessinger, E.
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Analysis of the monitoring network of substation as a complex network

, 2013
The electrical equipments as the most important part in the Substation need to be monitored usually. Here we study the network of Substation, which represents the distribution of state monitoring equipments in the Substation, as a complex network.
Zhang HY(张宏宇), Cui SJ(崔世界), Ge WC(葛维春), Shang ZJ(尚志军), Wang QS(王秋石)   +4 more
core  

Enhancing Resilience in China’s Refined Oil Product Distribution Network: A Complex Network Theory Approach with Optimization Strategies

Considering the escalating international geopolitical tensions and the ensuing great power maneuvers, China’s oil supply faced unprecedented threats.
Tongtong Hou, Lin Lin, Qingning Shen, Cen Song   +3 more
core   +1 more source

Corrigendum: Multi-person feature fusion transfer learning-based convolutional neural network for SSVEP-based collaborative BCI

Frontiers in Neuroscience, 2022
Penghai Li, Jianxian Su, Abdelkader Nasreddine Belkacem, Longlong Cheng, Chao Chen   +4 more
doaj   +1 more source

Vulnerability Analysis of a Multilayer Logistics Network against Cascading Failure

Algorithms
One of the most challenging issues in contemporary complex network research is to understand the structure and vulnerability of multilayer networks, even though cascading failures in single networks have been widely studied in recent years.
Tongyu Wu, Minjie Li, Shuangjiao Lin
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Wildlife tourism, science and actor network theory [PDF]

, 2009
Wildlife tourism is an important component of tourism worldwide. However, for many species little is known about the possible impacts from tourist-wildlife interactions.
Newsome, D., Rodger, K., Moore, S.A.
core