Results 131 to 140 of about 15,651,318 (279)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Complex Network Traffic Signal Optimized Model and Simulation

, 2015
In urban road traffic system, an important issue with the expansion of the network, resulting in the increasing complexity of the network, in-depth analysis of complex network operating mechanism is to further optimize and control network traffic and ...
Bi X(毕欣), Du JS(杜劲松), Zhao YN(赵越南), Wang W(王伟)   +3 more
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Examining Modulations of Internal Tides within An Anticyclonic Eddy Using a Wavelet-Coherence Network Approach

Applied Sciences
Interactions between internal tides and mesoscale eddies are an important topic. However, examining modulations of internal tides inside a mesoscale eddy based on observations is difficult due to limited observation duration and inaccurate positioning ...
Gyuchang Lim, Jong-Jin Park
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Analysis on spatial correlation characteristics of transportation carbon intensity of China based on complex network theory

Nantong Daxue xuebao. Ziran kexue ban
It is of great significance to understand the variations and spatial correlation of carbon intensity in transportation industry for achieving the goals of energy conservation, emission reduction and "dual carbon".
XIE Qing;LIU Jiabao
doaj   +1 more source

Detecting quantum critical points in the t-[Formula: see text] Fermi-Hubbard model via complex network theory. [PDF]

Sci Rep, 2020
Bagrov AA, Danilov M, Brener S, Harland M, Lichtenstein AI, Katsnelson MI.   +5 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Optimization Model for Safeguarding Vulnerable Components in Integrated Energy Systems Based on Weighted Betweenness

Shanghai Jiaotong Daxue xuebao
Utilizing the complex network theory to mitigate vulnerabilities mitigation in integrated energy systems is significant for enhancing the resilience of sustained energy supply, especially against deliberate physical attacks and natural disasters.
ZHANG Chenwei, WANG Ying, LI Yaping, ZHANG Kaifeng
doaj   +1 more source