Results 111 to 120 of about 7,591,420 (248)
Network depth: identifying median and contours in complex networks [PDF]
, 2019 Centrality descriptors are widelyusedtoranknodesaccordingtospecificconcept(s)ofimportance.Despite the large number ofcentrality measures available nowadays, it is still poorly understood how to identify the node which can be considered as the ‘centre’ of
Manlio De Domenico +2 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
International Journal of Computer Mathematics, 2008 Zidong Wang 0001, Dong Yue 0001
openaire +2 more sources
Network Complexity of Foodwebs
CoRR, 2010 In previous work, I have developed an information theoretic complexity measure of networks. When applied to several real world food webs, there is a distinct difference in complexity between the real food web, and randomised control networks obtained by shuffling the network links.
openaire +3 more sources
Sensitivity of Complex Networks
CoRR, 2016 The sensitivity (i.e. dynamic response) of complex networked systems has not been well understood, making difficult to predict whether new macroscopic dynamic behavior will emerge even if we know exactly how individual nodes behave and how they are coupled.
Marco Tulio Angulo +3 more
openaire +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Defensive medicine and strategic interactions in physician–patient networks
, 2023 Sometimes physicians abandon high-risk procedures in favour of safer inferior treatments to reduce exposure to malpractice liability. This is called defensive medicine. It is known to increase healthcare costs besides having ethical implications. Network
Delpini, Danilo, Russu, Paolo
core
The complexity of computations by networks
IBM Journal of Research and Development, 1987 Summary: We survey the current state of knowledge concerning the computation of Boolean functions by networks, with particular emphasis on the addition and multiplication of binary numbers.
openaire +3 more sources