Results 121 to 130 of about 8,326,384 (290)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Q/W-band Observations toward Starless Cores in Orion (QWOSCO). I. Overview, Isotopologues, Isomers, and Complex Organics

The Astrophysical Journal Supplement Series
Molecular inventories in starless cores are powerful tools for probing the physical and chemical structures at the earliest stages of star formation. Wide-band spectral scans are invaluable for obtaining a comprehensive view of the chemical composition ...
Shih-Ying Hsu, Xunchuan Liu, Sheng-Yuan Liu, Tie Liu, Naomi Hirano, Mika Juvela, Kee-Tae Kim, Chin-Fei Lee, Shanghuo Li, Sheng-Jun Lin, Sheng-Li Qin, Dipen Sahu, Ken’ichi Tatematsu, Fengwei Xu, L. Viktor Tóth   +14 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Ice Sublimation in the Dynamic HD 100453 Disk Reveals a Rich Reservoir of Inherited Complex Organics

The Astrophysical Journal Letters
Protoplanetary disks around luminous young A-type stars are prime observational laboratories to determine the abundances of complex organic molecules (COMs) present during planet formation.
Alice S. Booth, Lisa Wölfer, Milou Temmink, Jenny Calahan, Lucy Evans, Charles J. Law, Margot Leemker, Shota Notsu, Karin Öberg, Catherine Walsh   +9 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

IDENTIFICATION OF COMPLEX ORGANIC MOLECULES IN THE HOT MOLECULAR CORE G335.79+0.17

Eurasian Physical Technical Journal
Observations of the massive star-forming region G335.79+0.17 reveal dense, hot molecular gas toward two cores, P1 and P2, traced by methyl cyanide, its isotopologue, methyl acetylene, formaldehyde and dust continuum emission.
A.A. Abdirakhman, A.Zh. Omar, N.Sh. Alimgazinova, D.R. Tuiakbayeva, D.Y. Baitursyn   +4 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The Spatial Distribution of Complex Organic Molecules in the L1544 Pre-stellar Core. [PDF]

Astrophys J Lett, 2016
Jiménez-Serra I, Vasyunin AI, Caselli P, Marcelino N, Billot N, Viti S, Testi L, Vastel C, Lefloch B, Bachiller R.   +9 more
europepmc   +1 more source