Results 111 to 120 of about 767,104 (296)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
An Automated Chemical Exploration of NGC 6334I at 340 au Resolution
The Astrophysical JournalMuch of the information gleaned from observations of star-forming regions comes from the analysis of their molecular emission spectra, particularly in the radio regime.
Samer J. El-Abd +5 more
doaj +1 more source
The census of complex organic molecules in the solar type protostar IRAS16293-2422
, 2014 Complex Organic Molecules (COMs) are considered crucial molecules, since they are connected with organic chemistry, at the basis of the terrestrial life.
Caux, E. +3 more
core +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Astrophysical Journal Supplement SeriesMolecular inventories in starless cores are powerful tools for probing the physical and chemical structures at the earliest stages of star formation. Wide-band spectral scans are invaluable for obtaining a comprehensive view of the chemical composition ...
Shih-Ying Hsu +14 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Ice Sublimation in the Dynamic HD 100453 Disk Reveals a Rich Reservoir of Inherited Complex Organics
The Astrophysical Journal LettersProtoplanetary disks around luminous young A-type stars are prime observational laboratories to determine the abundances of complex organic molecules (COMs) present during planet formation.
Alice S. Booth +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Estimation of interaction energy of some functional groups of medical substances with protein molecules in water condition [PDF]
, 2006 The basic energetic effects when forming organic substance complexes with protein molecules which determine thermodynamics of this process are examines using nonempirical quantum-chemical DFT method.
Bondarev, А. А., Smirnov, I. V.
core
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source