Results 91 to 100 of about 767,104 (296)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

ALMA Observations of Ethyl Formate toward Orion KL

, 2018
Orion KL is one of the prime templates of astrochemical and prebiotic chemical studies. We wish to explore more organic molecules with increasing complexity in this region.
Ge, J. X., Peng, Yaping, Rivilla, V. M., Zhang, Li, Zhou, Bing   +4 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Understanding of complex spin up-conversion processes in charge-transfer-type organic molecules

Nature Communications
Despite significant progress made over the past decade in thermally activated delayed fluorescence (TADF) molecules as a material paradigm for enhancing the performance of organic light-emitting diodes, the underlying spin-flip mechanism in these charge ...
Hyung Suk Kim, Sang Hoon Lee, Seunghyup Yoo, Chihaya Adachi   +3 more
doaj   +1 more source

Adsorption of two pesticides on a clay surface: a theoretical study [PDF]

, 2012
The contamination of water resources with many organic xenobiotic compounds poses a challenge to environmental sciences and technologies [1]. Although in many cases these contaminants are present only in small concentrations, the large variety of such ...
Carvalho, A. J. Palace, Dordio, A. V., Ramalho, J.P. Prates   +2 more
core  

DNA Nucleobase Synthesis at Titan Atmosphere Analog by Soft X-rays

, 2009
Titan, the largest satellite of Saturn, has an atmosphere chiefly made up of N2 and CH4 and includes traces of many simple organic compounds. This atmosphere also partly consists of haze and aerosol particles which during the last 4.5 gigayears have been
Abbate M., Abe I., Basile B., Coll P., d’Hendecourt L. B., Gerakines P. A., Gibb E. L., Glaser R., Grasset O., Griffith C. A., Gueymard C. A., Imanaka H., Imanaka H., Kerkhof O., Khare B. N., Khare B. N., Khare B. N., Kobayashi K., Kobayashi K., Kobayashi K., Kobayashi K., Lappi S. E., Lorenz R. D., Lowe C. U., McDonald G. D., McGuigan M., Miller S. L., Mitri G., Moore M. H., Neish C. D., Nuevo M., Oró J., Oró J., Oró J., Pietrogrande M. C., Pilling S., Ponnamperuma C., Pullman B., Sagan C., Tran B. N., Tran B. N., Wakamatsu H., Wang F., Yamada Y., Yamanashi H., Yuasa S.   +45 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Hunting for Complex Organic Molecules in the Interstellar Medium: The Role of Accurate Low-Cost Theoretical Geometries and Rotational Constants. [PDF]

J Phys Chem A, 2023
Barone V, Lazzari F.
europepmc   +1 more source

Magnetic Transformations in the Organic Conductor kappa-(BETS)2Mn[N(CN)2]3 at the Metal-Insulator Transition

, 2010
A complex study of magnetic properties including dc magnetization, 1H NMR and magnetic torque measurements has been performed for the organic conductor kappa-(BETS)2Mn[N(CN)2]3 which undergoes a metal-insulator transition at T_MI~25K.
A. H. Morrish, E. B. Yagubskii, L. Ouahab, L. V. Zorina, M. V. Kartsovnik, N. D. Kushch, O. M. Vyaselev, T. Ishiguro, W. Biberacher   +8 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source