Results 131 to 140 of about 767,104 (296)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

ALMASOP. The Localized and Chemically Rich Features near the Bases of the Protostellar Jet in HOPS 87

The Astrophysical Journal
HOPS 87 is a Class 0 protostellar core known to harbor an extremely young bipolar outflow and a hot corino. We report the discovery of localized, chemically rich regions near the bases of the two-lobe bipolar molecular outflow in HOPS 87 containing ...
Shih-Ying Hsu, Chin-Fei Lee, Sheng-Yuan Liu, Doug Johnstone, Tie Liu, Satoko Takahashi, Leonardo Bronfman, Huei-Ru Vivien Chen, Somnath Dutta, David J. Eden, Neal J. Evans II, Naomi Hirano, Mika Juvela, Yi-Jehng Kuan, Woojin Kwon, Chang Won Lee, Jeong-Eun Lee, Shanghuo Li, Chun-Fan Liu, Xunchuan Liu, Qiuyi Luo, Sheng-Li Qin, Dipen Sahu, Patricio Sanhueza, Hsien Shang, Kenichi Tatematsu, Yao-Lun Yang   +26 more
doaj   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Editorial: Theoretical Characterization of Astrophysical Species

Frontiers in Astronomy and Space Sciences, 2022
Malgorzata Biczysko, Roberto Linguerri, Majdi Hochlaf   +2 more
doaj   +1 more source

An ALMA Molecular Inventory of Warm Herbig Ae Disks. II. Abundant Complex Organics and Volatile Sulphur in the IRS 48 Disk

The Astronomical Journal
The Atacama Large Millimeter/submillimeter Array (ALMA) can probe the molecular content of planet-forming disks with unprecedented sensitivity. These observations allow us to build up an inventory of the volatiles available for forming planets and comets.
Alice S. Booth, Milou Temmink, Ewine F. van Dishoeck, Lucy Evans, John D. Ilee, Mihkel Kama, Luke Keyte, Charles J. Law, Margot Leemker, Nienke van der Marel, Hideko Nomura, Shota Notsu, Karin Öberg, Catherine Walsh   +13 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

An ALMA Study of Molecular Complexity in the Hot Core G336.99-00.03 MM1

The Astrophysical Journal
High-mass star formation involves complex processes, with the hot core phase playing a crucial role in chemical enrichment and the formation of complex organic molecules. However, molecular inventories in hot cores remain limited.
Chunguo Duan, Qian Gou, Tie Liu, Fengwei Xu, Xuefang Xu, Junlin Lan, Ke Wang, Laurent Pagani, Donghui Quan, Junzhi Wang, Xunchuan Liu, Mingwei He   +11 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

HOPS-288: A Laboratory for Complex Organics in Proto-binary/Proto-multiple Systems

The Astrophysical Journal
Complex organic molecules (COMs) in young stellar objects have attracted significant attention in recent years due to their potential connection to prebiotic chemistry and their utility as tracers of warm or shocked gas components.
Shih-Ying Hsu, Nadia M. Murillo, Chin-Fei Lee, Doug Johnstone, Tien-Hao Hsieh, Naomi Hirano, Leonardo Bronfman, Yo-Ling Chuang, David J. Eden, Shanghuo Li, Sheng-Jun Lin, Mark G. Rawlings, Ken’ichi Tatematsu, Sheng-Yuan Liu, Huei-Ru Vivien Chen, Kee-Tae Kim, Yi-Jehng Kuan, Woojin Kwon, Chang Won Lee, Jeong-Eun Lee, Tie Liu, Qiuyi Luo, Patricio Sanhueza, Hsien Shang   +23 more
doaj   +1 more source