Results 81 to 90 of about 131,099 (317)

Evaluating the Mahler measure of linear forms via Kronecker limit\n formulas on complex projective space [PDF]

, 2021
James Cogdell, Jay Jorgenson, Lejla Smajlović   +2 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

On piecewise isomorphism of some varieties

, 2011
Two quasi-projective varieties are called piecewise isomorphic if they can be stratified into pairwise isomorphic strata. We show that the m-th symmetric power $S^m(C^n)$ of the complex affine space $C^n$ is piecewise isomorphic to $C^{mn}$ and the m-th ...
Gusein-Zade, S. M., Luengo, I., Melle-Hernandez, A.   +2 more
core  

Torus Actions on Cohomological Complex Projective Spaces [PDF]

Proceedings of the American Mathematical Society, 1977
In this note, we will compute the Pontrjagin classes of those topological manifolds which have the same rational cohomology algebra as C P n C{P^n} and which admit effective topological T n {T^n} actions.
openaire   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

A Novel Latin Hypercube Algorithm via Translational Propagation

The Scientific World Journal, 2014
Metamodels have been widely used in engineering design to facilitate analysis and optimization of complex systems that involve computationally expensive simulation programs. The accuracy of metamodels is directly related to the experimental designs used.
Guang Pan, Pengcheng Ye, Peng Wang
doaj   +1 more source

The complex-symplectic geometry of SL(2,C)-characters over surfaces

, 2003
The SL(2)-character variety X of a closed surface M enjoys a natural complex-symplectic structure invariant under the mapping class group G of M. Using the ergodicity of G on the SU(2)-character variety, we deduce that every G-invariant meromorphic ...
Goldman, William M.
core   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Asymptotic behaviour of the sectional ring

Comptes Rendus. Mathématique
The theory of the Okounkov body is a usual tool for analyzing the asymptotic behaviour of the sectional ring of a line bundle over a projective manifold.
Wu, Xiaojun
doaj   +1 more source