Results 91 to 100 of about 8,967,370 (295)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Identification of Virulence Associated Region during Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus during Attenuation In Vitro: Complex Question with Different Strain Backgrounds. [PDF]

Viruses, 2021
Jiang Y, Tong W, Yu L, Li L, Gao F, Li G, Liu C, Chen P, Shen Q, Zhang Y, Zhou Y, Tong G.   +11 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Evaluation a of a layered approach to question answering over linked data [PDF]

, 2012
Walter S, Unger C, Cimiano P, Bär D. Evaluation a of a layered approach to question answering over linked data. Presented at the The 11th International Semantic Web Conference (ISWC 2012), Boston, USA.We present a question answering system architecture ...
Christina Unger, Philipp Cimiano, Bär, Daniel, Daniel Bär, Walter, Sebastian, Sebastian Walter, Cimiano, Philipp, Walter, Sebastian ; https://orcid.org/, Unger, Christina ; https://orcid.org/, Unger, Christina, Cimiano, Philipp ; https://orcid.org/   +10 more
core   +1 more source

Interactive Teaching Evaluation Method Based on KG-CQA

International Journal of Computational Intelligence Systems
Interactive teaching evaluation plays an important role in the development of modern education. Accurately evaluating teaching effectiveness can effectively promote the improvement of classroom education.
Shaojiao Qin, Lin Li
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Complex knowledge modelling with functional entity relationship diagrams [PDF]

, 2011
Modelling complex knowledge resources can be problematical as there is currently no formalism that can represent the nature of the data-seeking process at a conceptual level.
Hobbs, V.J., Pigott, D.J.
core  

3C: a framework for structured chain-of-thought decoding to improve correctness, coherence, and comprehensiveness

Journal of King Saud University: Computer and Information Sciences
This paper introduces the Correctness, Coherence, and Comprehensiveness CoT Decoding (3C) framework, which aims to enhance the performance of LLMs in complex reasoning tasks.
Guoquan Lu, Weixiao Zhan, Lin Peng, Li Li   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Texas Capitol Complex Update

Newsletter from the Texas Capitol Complex Project discussing news and updates about phase II, as well as other information related to construction and the implementation of the master plan for the state capitol complex adopted in ...
State of Texas Capitol Complex Project
core   +2 more sources