Results 81 to 90 of about 8,967,370 (295)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Adaptive evolution of complex innovations through stepwise metabolic niche expansion
Nature Communications, 2016 A fundamental question in evolutionary biology is how complex innovations requiring multiple genetic changes arise. Here the authors provide lines of evidence that changing environments facilitate the adaptive evolution of complex metabolic innovations ...
Balázs Szappanos +12 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2019 Individuelle et collective, naturelle et sociale, théorique et pratique, la question de la violence traverse de nombreuses réflexions contemporaines. Qu’elle y soit souterraine, figée ou évacuée comme problème, elle est parfois formulée en des termes qui
La question de la violence
core
大数据, 2021 Recently, knowledge graph based question answering has been widely used in many fields such as medical care, finance, and government affairs.Users are no longer satisfied with question answering service of single-hop entity attributes, but want service ...
Huifang DU +3 more
doaj
The Mechanism of Action of Biguanides: New Answers to a Complex Question. [PDF]
Cancers (Basel), 2022 Di Magno L +4 more
europepmc +1 more source
The complex prosody of complex wh-questions
Isogloss. Open Journal of Romance LinguisticsIn this paper, we investigate the prosody of wh-questions with a complex wh-phrase, focusing on the role of the presence of a lexical restriction (e.g., what book) and of D(iscourse)-linking of the wh-phrase in the distribution of the main prosodic prominence (or nuclear pitch accent [NPA]). Through three read-aloud production studies, we show that the
Maria Francesca Ferin +3 more
openaire +2 more sources
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Planning an Healthcare Network: the case of Clinical Laboratories in Sicily
, 2014 Healthcare centers, private and public, are responsible for serving health demand of the population. Typically their respective geographical location and size is the result of a complex interaction between epidemiological, historical and economical ...
Sergio Pagano, Pierpaolo Cavallo
core +1 more source
Romain Rolland et l’URSS : engagement politique et vision cosmique dans L’Annonciatrice
Itinéraires, 2011 The relations between Romain Rolland and communism cannot be considered independently from the spiritual question. L’Annonciatrice, the last part of L’Âme enchantée, offers a succession of portraits that show the complex relationship between the ...
Roland Roudil
doaj +1 more source