Results 71 to 80 of about 8,967,370 (295)
Easy-to-Hard: Leveraging Simple Questions for Complex Question Generation
CoRR, 2019 This paper makes one of the first efforts toward automatically generating complex questions from knowledge graphs. Particularly, we study how to leverage existing simple question datasets for this task, under two separate scenarios: using either sub-questions of the target complex questions, or distantly related pseudo sub-questions when the former are
Jie Zhao 0013 +2 more
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Applied SciencesThe multi-granularity temporal knowledge graph question-answering model consists of two core tasks: question information extraction and knowledge graph embedding representation.
Yizhi Lu, Lei Su, Liping Wu, Di Jiang
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2011 Revised January 2011; application/pdf"This handbook was designed to provide information to parents, visitors and other interested individuals about the Kansas Juvenile Correctional Complex and its operation."Introduction General Programming ...
Kansas Juvenile Correctional Complex.
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Efficient question answering with question decomposition and multiple answer streams [PDF]
, 2009 The German question answering (QA) system IRSAW (formerly: InSicht) participated in QA@CLEF for the fth time. IRSAW was introduced in 2007 by integrating the deep answer producer InSicht, several shallow answer producers, and a logical validator ...
Glöckner, Ingo +5 more
core +2 more sources
Paediatric early warning systems: not a simple answer to a complex question. [PDF]
Arch Dis Child, 2023 Roland D +12 more
europepmc +1 more source